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SIMVASTATIN, SODIUM SALT

SIMVASTATIN, SODIUM SALT Structure
CAS No.
101314-97-0
Chemical Name:
SIMVASTATIN, SODIUM SALT
Synonyms
Simvastati;Simvasatin Ep Imp A;SIMVASTATIN, SODIUM SALT;FYSMQCWXGBXWLB-VMCZNHHFSA-M;Simvastatin Impurity 1（EP-A）;Simvastatin Acid Sodium Salt;Simvastatin hydroxy acid sodium;Simvastatin Impurity as Sodium Salt;SimvastatinEPImpurityA-d6SodiumSalt;SIMVASTATIN HYDROXY ACID SODIUM SALT
CBNumber:
CB8320771
Molecular Formula:
C25H41NaO6
Molecular Weight:
460.59
MOL File:
Mol file
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:06
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SIMVASTATIN, SODIUM SALT Properties

Melting point >122°C (dec.)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form White powder solid.
color White to Pale Beige
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H303-H361
Precautionary statements  P201-P202-P280-P312-P405-P501

SIMVASTATIN, SODIUM SALT Chemical Properties,Uses,Production

Description

Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-κB activation (IC50 = ~13 μM) and potentiates apoptosis in human myeloid leukemia cells. It also inhibits glutathione peroxidase 4 (GPX4) activity, increases malondialdehyde (MDA) levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells. Formulations containing simvastatin have been used in the treatment of dyslipidemias.

Uses

Simvastatin Hydroxy Acid Sodium Salt is a metabolite of Simvastatin (S485000), a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.

SIMVASTATIN, SODIUM SALT Preparation Products And Raw materials

Raw materials

Lovastatin Triol Acid Sodium Salt 2,2-Dimethylbutyryl chloride 3-[(2,2-Dimethyl-1-oxobutyl)thio]propanoic acid methyl ester Lovastatin

Preparation Products

SIMVASTATIN, SODIUM SALT Suppliers

Global( 83)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
GLP Pharma Standards +91 9866074638 Hyderabad, India 1644 58 Inquiry
Scinva Chemicals and Pharmaceuticals Pvt Ltd +91-7406196725 +91-7406196725 Karnataka, India 71 58 Inquiry
Vishrudh laboratories pvt ltd +91-9666132889 +91-8097369002 Telangana, India 117 58 Inquiry
Varanous Labs Pvt Ltd +91-7036248882 +91-7036248882 Hyderabad, India 1541 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9626 58 Inquiry
sgtlifesciences pvt ltd +8617013299288 China 12382 58 Inquiry
Supplier Advantage
GLP Pharma Standards 58
Scinva Chemicals and Pharmaceuticals Pvt Ltd 58
Vishrudh laboratories pvt ltd 58
Varanous Labs Pvt Ltd 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
BOC Sciences 58
Career Henan Chemica Co 58
Finetech Industry Limited 58
sgtlifesciences pvt ltd 58

101314-97-0(SIMVASTATIN, SODIUM SALT)Related Search:

Simvastatin ammonium salt 6'-EXOMETHYLENE SIMVASTATIN Simvastatin SiMvastatin EP IMpurity G AnhydrosiMvastatin
Lovastatin Epi Lovastatin SiMvastatin EP IMpurity G Simvastatin Dimer SiMvastatinAcetate Ester
Dehydro Simvastatin MONACOLIN J ACETYLSIMVASTATIN SiMvastatin Hydroxy Acid Ethyl Ester Simvastatin Hydroxy Acid Methyl Ester
SiMvastatin 4'-Methyl Ether 2′-Ethyl Simvastatin SiMvastatin Methyl Ester
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SIMVASTATIN HYDROXY ACID SODIUM SALT SIMVASTATIN, SODIUM SALT IMp. A (EP) as SodiuM Salt: (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-DiMethylbutanoyl)oxy]-2,6-diMethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid SodiuM Salt (Tenivastatin SodiuM Salt Simvastatin Impurity as Sodium Salt Simvastati SiMvastatin IMp. A (EP) as SodiuM Salt sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate Simvastatin hydroxyl acid sodium salt-d6 Simvastatin EP Impurity A Sodium Salt FYSMQCWXGBXWLB-VMCZNHHFSA-M Sodium (3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyheptanoate Simvastatin Impurity 1(Simvastatin EP Impurity A) Simvastatin Impurity 1（EP-A） Simvastatin hydroxy acid sodium Simvasatin Ep Imp A Simvasatin EP Impurity A/ Simvasatin Related Compound A (Simvastatin Sodium/ Tenivastatin Sodium) Simvastatin hydroxyl acid D6 Sodium salt Simvastatin EP Impurity AQ: What is Simvastatin EP Impurity A Q: What is the CAS Number of Simvastatin EP Impurity A Q: What is the storage condition of Simvastatin EP Impurity A Q: What are the applications of Simvastatin EP Impurity A Simvastatin Acid Sodium Salt Simvastatin Impurity A sodium salt（EP） SimvastatinEPImpurityA-d6SodiumSalt Simvastatin Impurity A as Sodium Salt Simvastatin EP Impurity A as Sodium Salt Simvastatin Impurity 1 Sodium Salt(Simvastatin EP Impurity A Sodium Salt) 1-Naphthaleneheptanoic acid,8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-b,d-dihydroxy-2,6-dimethyl-, monosodium salt, [1S-[1a(bS*,dS*),2a,6b,8b,8aa]]- 101314-97-0 12009-77-6 C25H39O6Na