PIROMIDIC ACID
- CAS No.
- 19562-30-2
- Chemical Name:
- PIROMIDIC ACID
- Synonyms
- pd93;PuriM;reelon;uropir;pirodal;enterol;Pirudal;panacid;septural;lidinyl)-
- CBNumber:
- CB3690633
- Molecular Formula:
- C14H16N4O3
- Molecular Weight:
- 288.3
- MOL File:
- 19562-30-2.mol
- Modify Date:
- 2023/6/8 9:02:37
| Melting point | 314-316° |
|---|---|
| Boiling point | 430.54°C (rough estimate) |
| Density | 1.1895 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | 0-6°C |
| solubility | Chloroform (Slightly, Heated, Sonicated), Ethanol (Slightly, Heated) |
| form | Solid |
| pka | 4.14±0.20(Predicted) |
| color | Crystals from EtOH/CHCl3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 287, 268, 177, 158 i.v.; all >4000 orally, s.c. and i.p. (Shimizu) | |||||||||
| NFPA 704 |
|
PIROMIDIC ACID Chemical Properties,Uses,Production
Description
Piromidic acid is a quinolone antibiotic that is active against Gram-positive and Gram-negative bacteria including S. aureus and E. coli (MICs = 10 and 1 μg/ml, respectively). It inhibits growth of nalidixic acid-sensitive strains of E. coli in an in vitro model of bacterial cystitis when used at concentrations of 10 and 50 mg/L. Piromidic acid also has antimalarial properties and is active against chloroquine-sensitive and -resistant strains of P. falciparum in vitro (IC50s = 41.4 and 14.4 μg/ml, respectively) as well as against hepatic stages of P. yoelii yoelii (IC50 = 21.6 μg/ml).
Uses
Piromidic acid is a quinolone antibacterial.
Pharmaceutical Applications
A pyrimidopyrimidine derivative with a C7-pyrrolidinyl ring, allowing a slight increase in activities against Gram-positive cocci. Its main antibacterial activity is close to that of nalidixic acid and there have been reports of renal toxicity. It is available in only a few countries.
Safety Profile
Poison by subcutaneous and intravenous routes. Moderately toxic by skin contact and intraperitoneal routes. An antibacterial agent. When heated to decomposition it emits toxic fumes of NOx.
PIROMIDIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9624 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | China | 2981 | 58 | Inquiry |
| Shanghai Hao Biological Technology Co., Ltd. | 021-58116080 18019263206 | CHINA | 6921 | 58 | Inquiry |
| Xiamen Research Biotechnology Co., Ltd. | 0592-6020891 18906011628 | CHINA | 6942 | 58 | Inquiry |
| Shanghai Yubo Biotechnology Co., Ltd. | 021-51875103 15026509758 | CHINA | 6322 | 58 | Inquiry |
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