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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Neuronal Signaling >Adrenergic Receptor Antagonists >(S)-Timolol maleate

(S)-Timolol maleate

(S)-Timolol maleate Structure
CAS No.
26921-17-5
Chemical Name:
(S)-Timolol maleate
Synonyms
TIMOLOL MALEATE;Timolol maleate CRS;TimoL;timoptic;2-Propanol, 1-(1,1-dimethylethyl)amino-3-4-(4-morpholinyl)-1,2,5-thiadiazol-3-yloxy-, (2S)-, (2Z)-2-butenedioate (1:1) (salt);mk950;Betim;betime;Tenopt;WP 934
CBNumber:
CB3711352
Molecular Formula:
C17H28N4O7S
Molecular Weight:
432.49
MOL File:
26921-17-5.mol
MSDS File:
SDS
Modify Date:
2025/2/21 21:32:25
Request For Quotation

(S)-Timolol maleate Properties

Melting point 202-203 °C(lit.)
alpha 24405 -12.0° (c = 5 in 1N HCl); D25 -4.2°
storage temp. 2-8°C
solubility H2O: soluble
form powder
color white to off-white
optical activity [α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.)
Water Solubility H2O: soluble
ethanol: soluble
ε(extinction coefficient) 8,700 at 294nm at 1M
Merck 14,9444
InChIKey WLRMANUAADYWEA-NWASOUNVSA-N
CAS DataBase Reference 26921-17-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H361
Precautionary statements  P280-P301+P312+P330
Hazard Codes  Xn,Xi
Risk Statements  22-63-36/37/38
Safety Statements  36-37/39-26
WGK Germany  3
RTECS  UA8475000
HS Code  29349990
NFPA 704
0
2 0

(S)-Timolol maleate price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) T6394 Timolol maleate salt ≥98% (TLC), powder 26921-17-5 100MG ₹8097.1 2022-06-14 Buy
Sigma-Aldrich(India) T6394 Timolol maleate salt ≥98% (TLC), powder 26921-17-5 250MG ₹16291.63 2022-06-14 Buy
Sigma-Aldrich(India) T6394 Timolol maleate salt ≥98% (TLC), powder 26921-17-5 1G ₹53269.83 2022-06-14 Buy
Sigma-Aldrich(India) PHR2593 Timolol Maleate 26921-17-5 500MG ₹18142.7 2022-06-14 Buy
Product number Packaging Price Buy
T6394 100MG ₹8097.1 Buy
T6394 250MG ₹16291.63 Buy
T6394 1G ₹53269.83 Buy
PHR2593 500MG ₹18142.7 Buy

(S)-Timolol maleate Chemical Properties,Uses,Production

Description

Timolol is a non-selective β-adrenergic receptor antagonist with log Kd values of -8.27, -9.86, and -6.8 for binding to human β1-, β2-, and β3-adrenoceptors, respectively. It has been reported that only the (S) enantiomer contributes to the β-blocking effects of racemic timolol, but the weakly active (R) isomer maintains a beneficial effect on intraocular pressure without the undesirable side-effect of bronchial constriction caused by non-selective action of (S)-timolol on β1 and β2 receptors. Timolol has been use alone and in fixed combinations with either prostaglandin analogs or carbonic anhydrase inhibitors to reduce intraocular pressure in research models of ocular hypertension and glaucoma.

Chemical Properties

White Solid

Uses

betaadrenergic blocker

Definition

ChEBI: The maleic acid salt of the active (S)-enantiomer of timolol, comprising equimolar amounts of (S)-timolol and maleic acid.

Biological Activity

β 1 -adrenergic blocker.

(S)-Timolol maleate Preparation Products And Raw materials

Raw materials

tert-Butylamine Tosyl chloride Sodium borohydride Maleic acid

Preparation Products

(S)-Timolol maleate Suppliers

Global( 320)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Flax Laboratories +91-9867665132 +91-9867665132 Maharashtra, India 44 58 Inquiry
FDC Limited +912226782653 Mumbai, India 30 58 Inquiry
Centaur Pharmaceuticals Pvt Ltd +912266499100 Mumbai, India 33 58 Inquiry
Precise Biopharma Pvt Ltd +91-2267828600 +91-2267828600 Maharashtra, India 46 58 Inquiry
Global Calcium Pvt Ltd +91-8050750904 +91-8040554500 Karnataka, India 132 58 Inquiry
Besil Chem LLP +91-7760252666 +91-9880731835 Bangalore, India 163 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Ven Petrochem And Pharma Pvt Ltd +91-2226590160 +91-9821133770 Maharashtra, India 4 58 Inquiry
Medilux Laboratories Pvt Ltd +91-7292409991 +91-9819666688 Madhya Pradesh, India 102 58 Inquiry
Enaltec Labs Pvt Ltd +91-9167119247 +91-9167119247 Maharashtra, India 49 58 Inquiry
Supplier Advantage
Flax Laboratories 58
FDC Limited 58
Centaur Pharmaceuticals Pvt Ltd 58
Precise Biopharma Pvt Ltd 58
Global Calcium Pvt Ltd 58
Besil Chem LLP 58
Ralington Pharma 58
Ven Petrochem And Pharma Pvt Ltd 58
Medilux Laboratories Pvt Ltd 58
Enaltec Labs Pvt Ltd 58

(S)-Timolol maleate Spectrum

(S)-Timolol maleate(26921-17-5)1HNMR

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S[-]-1-[T-BUTYLAMINO]-3-(4-MORPHOLINO-1,2,5-THIADIAZOL-3-YL)OXY]-2-PROPANOL MALEATE SALT (S)-1-[(1,1-DIMETHYLETHYL)AMINO]-3-[[4-(4-MORPHOLINYL)-1,2,5-THIADIAZOL-3-YL]OXY]-2-PROPANOL MALEATE (s)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol (z)-2-butenedioate (1:1) (-)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-2-propan (s)-timololhydrogenmaleate 1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-2-propano( betime l-timololmaleate mk950 olmaleate timacor TIMOLOL MALEATE USP 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2S)-, (2Z)-2-butenedioate (1:1) (salt) (9CI) 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (S)-, (Z)-2-butenedioate (1:1) (salt) Aquanil Betim Blocanol Optimol Proflax Rysmon TG Temserin Tenopt Timacar Timoptol Timoptol XE Timorom WP 934 (S)-3-[3-(tert.-Butylamino)-2-hydroxypropoxy]-4-morpholino-1,2,5-thiadiazolmonomaleat 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2S)-, (2Z)-2-butenedioate (1:1) Timolol maleate, >=99% Timclol Maleate (2S)-1-(tert-Butylamino)-3-(4-morpholino-1,2,5-thiadiazole-3-yloxy)-2-propanol·maleic acid Thiaboot Timabak Timolol hydrgenmaleate Timolol Maleate (200 mg) ToMolol Maleate (2S)-1-[(1,1-DiMethylethyl)aMino]-3-[[4-(4-Morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]- (S)-1-(tert-butylaMino)-3-((4-Morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol Maleate Hydrogen maleate salt Timolol for system suitability TIMOLOL HYDROGENMALEATE TIMOLOL MALEATE SALT (S)-TIMOLOL MALEATE (s)-3-[3-(tert-butylamino)-2-hydroxypropoxy]-4-morpholino-1,2,5-thiadiazole monomaleate S-(-)-1-[T-BUTYLAMINO]-3-[(4-MORPHOLINO-1,2,5-THIADIAZOL-3-YL)OXY]-2-PROPANOL MALEATE SALT tert-butyl-[(2S)-2-hydroxy-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]propyl]ammonium Timolol for system suitability CRS L-714,465 (Maleate) (S)-Timolol maleate USP/EP/BP Timolol Maleate (L-714,465 Maleate Timolol maleateQ: What is Timolol maleate Q: What is the CAS Number of Timolol maleate Q: What is the storage condition of Timolol maleate Q: What are the applications of Timolol maleate Timolol for system suitability (Y0001270)Q: What is Timolol for system suitability (Y0001270) Q: What is the CAS Number of Timolol for system suitability (Y0001270) Timolol Maleate (1667406) timoptic 2-Propanol, 1-(1,1-dimethylethyl)amino-3-4-(4-morpholinyl)-1,2,5-thiadiazol-3-yloxy-, (2S)-, (2Z)-2-butenedioate (1:1) (salt) TIMOLOL MALEATE Timolol maleate CRS