Enalapril maleate
- CAS No.
- 76095-16-4
- Chemical Name:
- Enalapril maleate
- Synonyms
- Olivin;Renitek;Renivace;Enalapril Maleate Salt;(S)-1-((S)-2-((S)-1-ETHOXY-1-OXO-4-PHENYLBUTAN-2-YLAMINO)PROPANOYL)PYRROLIDINE-2-CARBOXYLIC ACID MALEATE;BQL;Pres;Ednyt;Envas;Nuril
- CBNumber:
- CB1467853
- Molecular Formula:
- C24H32N2O9
- Molecular Weight:
- 492.52
- MOL File:
- 76095-16-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/28 16:56:32
| Melting point | 143-144,5°C |
|---|---|
| Boiling point | 0°C |
| alpha | D25 -42.2° (c = 1 in methanol) |
| Flash point | 0°C |
| storage temp. | 2-8°C |
| solubility | methanol: ≥50 mg/mL, clear, colorless to yellow |
| form | powder |
| pka | pKa1 3.0; pKa2 (25°) 5.4 |
| color | white to off-white |
| Water Solubility | Soluble in water, methanol, and ethanol. |
| λmax | 208nm(MeOH)(lit.) |
| Merck | 14,3567 |
| BCS Class | 1 (LogP), 3 (CLogP) |
| InChIKey | OYFJQPXVCSSHAI-QFPUQLAESA-N |
| CAS DataBase Reference | 76095-16-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361fd | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-62-63 | |||||||||
| Safety Statements | 22-24/25-36/37-26 | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | TW3666000 | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | LD50 oral in rat: 2973mg/kg | |||||||||
| NFPA 704 |
|
Enalapril maleate price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E6888 | Enalapril maleate salt powder, ≥98% (TLC) | 76095-16-4 | 250MG | ₹5639.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1289 | Enalapril Maleate Pharmaceutical Secondary Standard; Certified Reference Material | 76095-16-4 | 1G | ₹8107.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E6888 | Enalapril maleate salt powder, ≥98% (TLC) | 76095-16-4 | 1G | ₹15501.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E6888 | Enalapril maleate salt powder, ≥98% (TLC) | 76095-16-4 | 5G | ₹56809.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 16616 | Enalapril maleate salt analytical standard | 76095-16-4 | 50MG | ₹6181.08 | 2022-06-14 | Buy |
Enalapril maleate Chemical Properties,Uses,Production
Description
Enalapril maleate is the second angiotensin converting enzyme inhibitor to reach the marketplace. Like captopril, the first entry in this area, enalapril is useful in the treatment of hypertension and congestive heart failure. It has a longer effective half-life than captopril, allowing once or twice-daily dosing, and appears to have a somewhat lower incidence of side effects.
Chemical Properties
White to Off-White Crystalline Powder
Uses
Enalapril maleate salt is used as a long-acting ACE inhibitor and antihypertensive, used to study diabetic angiopathy in diabetic rats and inhibition of ACE in hog plasma (I50=1.2nM). ACE inhibitors disturb the enin-angiotensin- aldosterone system. Additional ACE inhibitors include: Enalapril, Enalaprilat dihydrate, Enalaprilat, and Enalapril-d5 Maleate Salt, among others.
Definition
ChEBI: The maleic acid salt of enalapril. It contains one molecule of maleic acid for each molecule of enalapril. Following oral administration, the ethyl ester group of enalapril is hydrolysed to afford the corresponding carboxylic acid, enalaprilat, an angioten in-converting enzyme (ACE) inhibitor. Enalapril is thus a prodrug for enalaprilat (which, unlike enalapril, is not absorbed by mouth), and its maleate is used in the treatment of hypertension and heart failure, for reduction of proteinuria and renal diseas in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients.
General Description
Enalapril maleate, 1-[N[(S)-1-carboxy-3-phenylpropyl]-L-alanyl]-L-proline 1 -ethyl estermaleate (Vasotec), is a long-acting ACE inhibitor. It requiresactivation by hydrolysis of its ethyl ester to form thediacid enalaprilat. Enalapril is devoid of the side effects ofrash and loss of taste seen with captopril. These side effectsare similar to those of the mercapto-containing drugpenicillamine. The absence of the thiol group in enalaprilmaleate may free it from these side effects. The half-life is11 hours.
Enalapril maleate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Nosch Labs Pvt Ltd | +91-4048557474 +91-9948222287 | Hyderabad, India | 58 | 58 | Inquiry |
| Besil Chem LLP | +91-7760252666 +91-9880731835 | Bangalore, India | 163 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Alfa Omega Pharma | +91-8050045945 +91-9972665399 | Maharashtra, India | 126 | 58 | Inquiry |
| Sri Krishna Pharmaceuticals Ltd | +91-4027177825 +91-8886992503 | Telangana, India | 13 | 58 | Inquiry |
| Vijaya Pharma And Life Science | +91-8939866271 +91-8939866271 | Tamil Nadu, India | 320 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SNECOFRi Pvt Ltd | 58 |
| Dr. Reddy's Laboratories Ltd | 58 |
| KARPSCHEM LABORATORIES | 58 |
| Hetero Drugs Limited | 58 |
| Nosch Labs Pvt Ltd | 58 |
| Besil Chem LLP | 58 |
| Ralington Pharma | 58 |
| Alfa Omega Pharma | 58 |
| Sri Krishna Pharmaceuticals Ltd | 58 |
| Vijaya Pharma And Life Science | 58 |
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