ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Pancreatic hormone and blood sugar regulation >Epalrestat
Epalrestat
- CAS No.
- 82159-09-9
- Chemical Name:
- Epalrestat
- Synonyms
- 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo;2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid;e)-(e;Ipast;Eabeth;Epatat;Kinedak;Epa－API;Ipastat;ONO 2235
- CBNumber:
- CB6312501
- Molecular Formula:
- C15H13NO3S2
- Molecular Weight:
- 319.4
- MOL File:
- 82159-09-9.mol
- Modify Date:
- 2024/4/24 17:21:45
| Melting point | 210-217 C |
|---|---|
| Boiling point | 516.8±60.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | 3.62±0.10(Predicted) |
| form | powder |
| color | yellow to orange |
| Merck | 14,3605 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| InChI | InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8- |
| InChIKey | CHNUOJQWGUIOLD-NFZZJPOKSA-N |
| SMILES | S1/C(=C\C(\C)=C\C2=CC=CC=C2)/C(=O)N(CC(O)=O)C1=S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310+P330-P405-P501 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XJ5131855 | |||||||||
| HS Code | 2932.99.7000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| NFPA 704 |
|
Epalrestat price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0527 | Epalrestat ≥98% (HPLC) | 82159-09-9 | 10MG | ₹12297.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0527 | Epalrestat ≥98% (HPLC) | 82159-09-9 | 50MG | ₹50076.45 | 2022-06-14 | Buy |
| TCI Chemicals (India) | E0906 | Epalrestat | 82159-09-9 | 1G | ₹7200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | E0906 | Epalrestat | 82159-09-9 | 5G | ₹9800 | 2022-05-26 | Buy |
Epalrestat Chemical Properties,Uses,Production
Description
Epalrestat is the second aldose reductase inhibitor to be introduced worldwide and the first to be launched in Japan. The compound is indicated for the treatment of diabetic neuropathy. It is also being investigated for diabetic retinopathy and nephropathy.
Chemical Properties
Red Solid
Uses
Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM
Definition
ChEBI: A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
Epalrestat Preparation Products And Raw materials
Raw materials
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Global( 469)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GMFC LABS PVT LTD | +91-9133370278 +91-9133370278 | Hyderabad, India | 44 | 58 | Inquiry |
| Metrochem API Private Limited | +91-4069069999 +91-4069069999 | Telangana, India | 78 | 58 | Inquiry |
| Viyash Life Sciences Pvt Ltd | +91-4023635052 +91-4023635052 | Telangana, India | 213 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Symed Laboratories Ltd | +91-9505426644 +91-9505426644 | Telangana, India | 54 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| MANGALAM DRUGS AND ORGANICS LIMITED | 08147509329 | Uttar Pradesh, India | 50 | 58 | Inquiry |
82159-09-9(Epalrestat)Related Search:
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5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet
e)-(e
EPALRESTAT
(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
AKOS BBS-00007767
OTAVA-BB BB7211260020
Epalrest
Epalrestat, 99.5%
EPALRESTAT(KINEDAK)
5-[(1Z,2E)-2-METHYL-3-PHENYLPROPENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINEACETICACID(EPALRESTAT)
ONO 2235
Epalresta
2-((E)-5-((E)-2-METHYL-3-PHENYLALLYLIDENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)ACETIC ACID
Epatrestat
3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-
5-((1Z,2E)-2-Methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
[5-[(1Z,2E)-2-Methyl-3-phenylallylidene]-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
Eabeth
Epatat
Quinedac
Kinedak
(E，E)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-3-thiazo-lidineaeetic acid
(5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic Acid
He IpaneMa Division
2-[(5Z)-5[(E)-3-PHENIL-2-METHYLPROP-2-ENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINYL] ACETIC ACID
Epalrestat>
Epalrestat Epalrestat
Epalrestat RS
3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)-
Epalrestat USP/EP/BP
Epalrestat (ONO2235)
EpalrestatQ: What is
Epalrestat Q: What is the CAS Number of
Epalrestat Q: What is the storage condition of
Epalrestat Q: What are the applications of
Epalrestat
Epa－API
Ipastat
According to Mr He
2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid
3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo
Antidiabetic API
Ipasetam
Ipast
82159-09-9
81259-09-9
C15H13NO3S2
API
Hormone Drugs
Aromatics
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals
Sulfur & Selenium Compounds
API's
Treatment of diabetic neuropathy
82159-09-9