ALMOTRIPTAN
- CAS No.
- 181183-52-8
- Chemical Name:
- ALMOTRIPTAN
- Synonyms
- Axert;Almogran;PNU 180638;PNU-180638;Almotriptan;LAS-31416 Malate;1-[[[3-[2-(dimeth;Amotriptan malate;AlmotriptanMaleate;ALMOTRIPTAN MALATE
- CBNumber:
- CB2417037
- Molecular Formula:
- C21H31N3O7S
- Molecular Weight:
- 469.55
- MOL File:
- 181183-52-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/10/31 16:47:27
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H312-H332 | |||||||||
| Precautionary statements | P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501 | |||||||||
| HS Code | 2935904000 | |||||||||
| NFPA 704 |
|
ALMOTRIPTAN price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1210 | Almotriptan malate ≥98% (HPLC) | 181183-52-8 | 10MG | ₹13563.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1210 | Almotriptan malate ≥98% (HPLC) | 181183-52-8 | 50MG | ₹54547.18 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A3111 | Almotriptan Malate | 181183-52-8 | 25MG | ₹5000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A3111 | Almotriptan Malate | 181183-52-8 | 100MG | ₹9200 | 2022-05-26 | Buy |
ALMOTRIPTAN Chemical Properties,Uses,Production
Description
Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay). It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate. Formulations containing almotriptan have been used in the treatment of migraine headaches.
Chemical Properties
Pale Yellow Solid
Uses
Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.
Definition
ChEBI: The malate salt of almotriptan.
General Description
Almotriptan, marketed in 2000, has the highest oralbioavailability among all triptans. It is metabolizedby both MAO-A and CYP3A4, thus has a more favorableside effects profile when compared with sumatriptan.However, it is only available in a 12.5 mg tablet form.
ALMOTRIPTAN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| SMS Pharmaceuticals Ltd | +91-8179850881 +91-9100092121 | Telangana, India | 22 | 58 | Inquiry |
| Venkatasai Life Sciences | +91-9908134868 +91-8008303069 | Hyderabad, India | 186 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Nosch Labs Pvt Ltd | +91-4048557474 +91-9948222287 | Hyderabad, India | 58 | 58 | Inquiry |
| Stereokem Pvt Ltd | +91-4029706929 +91-9394224843 | Telangana, India | 350 | 58 | Inquiry |
| SYNERGENE ACTIVE INGREDIENTS PVT. LIMITED | 97-40-23700794/23700994 | New Delhi, India | 41 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| Rensun Pharmaceuticals Pvt Ltd. | 91-22-28223755 | Maharashtra, India | 153 | 58 | Inquiry |