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Enalaprilat

Enalaprilat Structure
CAS No.
76420-72-9
Chemical Name:
Enalaprilat
Synonyms
Vasotec IV;Enalaprilat;MK 421 diacid;Enalapril acid;Enalapril diacid;Enalaprilic Acid;ENALAPRILAT HYDRATE;Enalaprilat USP/EP/BP;enalaprilat (anhydrous);Enalapril maleate impurity C
CBNumber:
CB3163049
Molecular Formula:
C18H24N2O5
Molecular Weight:
348.39
MOL File:
76420-72-9.mol
MSDS File:
SDS
Modify Date:
2023/5/4 15:11:55
Request For Quotation

Enalaprilat Properties

Melting point 148-151°C
alpha D -67.0° (0.1M HCl)
Boiling point 601.0±55.0 °C(Predicted)
Density 1.286±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Very slightly soluble or slightly soluble in water, sparingly soluble in methanol, practically insoluble in acetonitrile.
pka pKa 2.30 (Uncertain);3.39 (Uncertain)
Water Solubility Soluble in water with heating (~60°C)
CAS DataBase Reference 76420-72-9(CAS DataBase Reference)
EPA Substance Registry System L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl- (76420-72-9)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  2

Enalaprilat price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 43301 Enalaprilat analytical standard 76420-72-9 25MG ₹12513.7 2022-06-14 Buy
Product number Packaging Price Buy
43301 25MG ₹12513.7 Buy

Enalaprilat Chemical Properties,Uses,Production

Description

Enalaprilat is the diacid active metabolite of enalapril. As an injectable ACE inhibitor, it is reportedly useful in the treatment of uncomplicated accelerated hypertension and hypertensive emergencies. Enalaprilat is more effective in reducing blood pressure in the elderly than in the young, despite the fact that renin activity is lower in old age.

Chemical Properties

White Crystalline Solid

Uses

Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). Studies indicate that Enalapril downregulates the expression of IL-β, IL-6, and NF-κB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.

Definition

ChEBI: Enalapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid. Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor and is used (often in the form of its prodrug, enalapril) in the treatment of hypertension an heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is g ven by intravenous injection, usually as the dihydrate.

Enalaprilat Preparation Products And Raw materials

Raw materials

5-(2-phenylethyl)imidazolidine-2,4-dione Benzenebutanoic acid, α-bromo-, ethyl ester, (αR)- Benzenebutanoic acid, α-[(aminocarbonyl)amino]-, (αR)- (R)-2-Bromo-4-phenylbutyric acid Enalapril tert-Butyl Ester
Enalapril L-Alanyl-L-proline tert-Butyl Ester Phenylpropyl aldehyde Enalapril maleate 2-Oxo-4-phenylbutyric acid
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Preparation Products

N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine

Enalaprilat Suppliers

Global( 180)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Besil Chem LLP +91-7760252666 +91-9880731835 Bangalore, India 163 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Vyshno Bio Sciences 91-7095439993 Hyderabad, India 239 58 Inquiry
Anant Pharmaceuticals Pvt. ltd +91 8550986868 Maharashtra, India 736 58 Inquiry
Opulent Pharma 08068441147Ext 981 Gujarat, India 810 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Ralington Pharma 91-79-48911722 Gujarat, India 312 58 Inquiry
Besil Chem LLP 91--9880731835 Karnataka, India 65 58 Inquiry
Supplier Advantage
Besil Chem LLP 58
Ralington Pharma 58
CLEARSYNTH LABS LTD. 58
SynZeal Research Pvt Ltd 58
Vyshno Bio Sciences 58
Anant Pharmaceuticals Pvt. ltd 58
Opulent Pharma 58
Pharma Affiliates 58
Ralington Pharma 58
Besil Chem LLP 58

76420-72-9(Enalaprilat)Related Search:

Pyrrolidine cis-4-Hydroxy-L-proline Methyl 3-oxovalerate PHENYL VALERATE Propionyl bromide
L-PROLINE-(4-3H(N)) L-Alanyl-L-Glutamine Phenylhydrazine Enalapril maleate ALTRENOGEST
Glycine Propyl gallate Enalapril Propyl butyrate ENALAPRILAT DIHYDRATE,ENALAPRILAT USP
Nifedipine Eplerenone Idarubicin
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ENALAPRILAT HYDRATE ENALAPRILAT USP(CRM STANDARD) Enalapril acid L-Proline, 1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-, (S)- N-[1(S)-Carboxy-3-phenylpropyl]-L-alanyl-L-proline 1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]-L-proline Enalapril diacid (2S)-1-[(2S)-2-{[(2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]pyrrolidine-2-carboxylic acid Enalaprilat(Enalapril IMpurity C) N-[(1S)-1-Carboxy-3-phenylpropyl]-L-alanyl-L-proline L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl- (S)-1-((S)-2-(((S)-1-Carboxy-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid enalaprilat (anhydrous) Enalaprilic Acid N-[(1S)-1-(Carboxy)-3-phenylpropyl]-L-alanyl]-L-proline Dihydrate Vasotec IV (2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenyl-propyl]amino]propanoyl]pyrrolidine-2-carboxylic acid Enalaprilat Enalaprilat (Enalapril EP Impurity C) Enalapril maleate impurity C (2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-p Enalaprilat USP/EP/BP Enalaprilat DISCONTINUED. Please see E555375. Enalapril maleate EP Impurity C EnalaprilatQ: What is Enalaprilat Q: What is the CAS Number of Enalaprilat Q: What is the storage condition of Enalaprilat Q: What are the applications of Enalaprilat MK 421 diacid 76420-72-9 C18H28N2O7 C18H24N2O52H2O C18H24N2O5 Metabolite Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Various Metabolites and Impurities Active Pharmaceutical Ingredients