Eplerenone
- CAS No.
- 107724-20-9
- Chemical Name:
- Eplerenone
- Synonyms
- Inspra;EPLERINONE;Eplerenone CRS;Eplerenone [USAN];pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester;PREGNA-4-ENE-7,21-DICARBOXYLIC ACID,11,17-DIHYDROXY-3-OXO,G-LACTONE,METHYLESTER,(7Α,11Α,17Α);(7A,11A,17A)-9,11-EPOXY-17-HYDROXY-3-OXO-PREGN-4-ENE-7,21-DICARBOXYLIC ACID G-LACTONE METHYL ESTER;SC-66110;HSDB 7522;CGP 30083
- CBNumber:
- CB3489802
- Molecular Formula:
- C24H30O6
- Molecular Weight:
- 414.49
- MOL File:
- 107724-20-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/13 17:03:25
| Melting point | 241-243°C |
|---|---|
| alpha | D +5° (c = 0.437 in chloroform) |
| Boiling point | 597.9±50.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMSO: soluble2mg/mL, clear (warmed) |
| form | powder |
| color | white to beige |
| λmax | 240nm(lit.) |
| Merck | 14,3625 |
| InChIKey | UZZAHAKTLYRDOK-MGIDJNSKSA-N |
| SMILES | [C@@]123[C@@]4(C)CCC(=O)C=C4C[C@@H](C(OC)=O)[C@@]1([H])[C@]1([H])CC[C@]4(CCC(=O)O4)[C@]1(C[C@@]2([H])O3)C |&1:0,1,10,15,17,21,27,29,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| RIDADR | 3077 |
| WGK Germany | 3 |
| HS Code | 29322090 |
Eplerenone price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E6657 | Eplerenone ≥98% (HPLC) | 107724-20-9 | 10MG | ₹21152.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E6657 | Eplerenone ≥98% (HPLC) | 107724-20-9 | 50MG | ₹81772.05 | 2022-06-14 | Buy |
| TCI Chemicals (India) | E0905 | Eplerenone | 107724-20-9 | 200MG | ₹8800 | 2022-05-26 | Buy |
Eplerenone Chemical Properties,Uses,Production
Description
Eplerenone is a mineralocorticoid receptor antagonist. It is selective for the mineralocorticoid receptor over glucocorticoid, androgen, progesterone, and estrogen receptors in radioligand binding assays (IC50s = 138, 6,920, 523, >10,000, and 5,702 nM, respectively). Eplerenone inhibits aldosterone-induced mineralocorticoid activity in a luciferase assay (IC50 = 122 nM). In vivo, eplerenone (100 mg/kg per day) reduces urinary albumin secretion and glomerulosclerosis in the Dahl salt-sensitive rat model of hypertension and nephropathy. It reduces myocardial IL-1β levels and collagen deposition, as well as improves left ventricular systolic dysfunction in a mouse model of acute myocardial infarction. Formulations containing eplerenone have been used in the treatment of hypertension and heart failure after myocardial infarction.
Chemical Properties
White Solid
Uses
Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.
General Description
Eplerenone, 9,11α-epoxy-17α-hydroxy-3-oxopregn-4-ene-7α,21-dicarboxylic acid, γ-lactone,methyl ester (Inspra), is a newer aldosterone antagonist that isused for the treatment of hypertension.
Biological Activity
Selective mineralocorticoid (aldosterone) receptor antagonist (IC 50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC 50 > 10 μ M). Orally active antihypertensive in vivo .
Clinical Use
A newer drug, eplerenone, has a structure similar to that of spironolactone and a similar mechanism of action. It was initially approved for use in the treatment of hypertension but it can now be used in the treatment of patients with left ventricular systolic dysfunction and congestive heart failure after myocardial infarction.
Eplerenone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| JPN Pharma Pvt Ltd | +919833233531 | Maharashtra, India | 33 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| Bioaltus Laboratories Pvt Ltd | +91-2249744539 +91-9820139885 | Maharashtra, India | 34 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Allastir Private Limited | +91-9840051621 +91-9791039207 | Tamil Nadu, India | 15 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
Related articles
- Pharmacology and Side Effects of Eplerenone
- Eplerenone is the second oral aldosterone antagonist available for the treatment of essential hypertension and heart failure. ....
- Aug 15，2019
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