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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Antihypertensive drugs >Eplerenone

Eplerenone

Eplerenone Structure
  • ₹8800 - ₹81772.05
  • Product name: Eplerenone
  • CAS: 107724-20-9
  • MF: C24H30O6
  • MW: 414.49
  • EINECS:600-850-8
  • MDL Number:MFCD05662207
  • Synonyms:(2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-Methyl 4a,6a-diMethyl-2,4'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate;HSDB 7522;Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-;Eplerenone intermediate Eplerenone;(7α,11α,17α)-9,11-epoxy-17-hydroxy-3-oxo-γ-lactone-pregn-4-ene-7,21-dicarboxylic acid-7-methyl ester;Eplerenone for system suitability;Eplerenone for peak identification;EPLERENONE
3 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 200MG
  • ManufacturerTCI Chemicals (India)
  • Product numberE0905
  • Product descriptionEplerenone
  • Packaging200MG
  • Price₹8800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberE6657
  • Product descriptionEplerenone ≥98% (HPLC)
  • Packaging10MG
  • Price₹21152.05
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberE6657
  • Product descriptionEplerenone ≥98% (HPLC)
  • Packaging50MG
  • Price₹81772.05
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) E0905 Eplerenone 200MG ₹8800 2022-05-26 Buy
Sigma-Aldrich(India) E6657 Eplerenone ≥98% (HPLC) 10MG ₹21152.05 2022-06-14 Buy
Sigma-Aldrich(India) E6657 Eplerenone ≥98% (HPLC) 50MG ₹81772.05 2022-06-14 Buy

Properties

Melting point :241-243°C
alpha :D +5° (c = 0.437 in chloroform)
Boiling point :597.9±50.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :DMSO: soluble2mg/mL, clear (warmed)
form :powder
color :white to beige
λmax :240nm(lit.)
Merck :14,3625
InChIKey :UZZAHAKTLYRDOK-MGIDJNSKSA-N
SMILES :[C@@]123[C@@]4(C)CCC(=O)C=C4C[C@@H](C(OC)=O)[C@@]1([H])[C@]1([H])CC[C@]4(CCC(=O)O4)[C@]1(C[C@@]2([H])O3)C |&1:0,1,10,15,17,21,27,29,r|

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Eplerenone is a potassium-sparing diuretic that selectively blocks aldosterone activation of the mineralcorticoid receptor (IC50 = 122 nM), demonstrating little activity towards other steroid receptors (IC50 > 9 μM for glucocorticoid, androgen, progesterone, and estrogen receptors). Aldosterone antagonists such as this compound have been indicated for the treatment of hypertension and heart failure.

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