ENALAPRILAT DIHYDRATE
- CAS No.
- 84680-54-6
- Chemical Name:
- ENALAPRILAT DIHYDRATE
- Synonyms
- MK-422;ENALAPRILATE;as dihydrate;ENALAPRILAT USP;MK-422 Dihydrate;Enalaprilate USP25;Vasotec IV Dihydrate;Enalaprilat (300 mg);ENALAPRILAT DIHYDRATE;Enalaprilat (1235274)
- CBNumber:
- CB5373019
- Molecular Formula:
- C18H26N2O6
- Molecular Weight:
- 366.41
- MOL File:
- 84680-54-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:11
| Melting point | 151-159°C |
|---|---|
| alpha | [α]D25 -53.0～-56.0゜ (c=1, CH3OH) (Calculated on dehydrous basis) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble14mg/mL at 60°C (warming for 5 minutes) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 84680-54-6(CAS DataBase Reference) |
| EPA Substance Registry System | L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-, hydrate (1:2) (84680-54-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TW3590600 | |||||||||
| HS Code | 2933995300 | |||||||||
| NFPA 704 |
|
ENALAPRILAT DIHYDRATE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E9658 | Enalaprilat dihydrate ≥98% (HPLC) | 84680-54-6 | 5MG | ₹14516.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E9658 | Enalaprilat dihydrate ≥98% (HPLC) | 84680-54-6 | 25MG | ₹54926.05 | 2022-06-14 | Buy |
| TCI Chemicals (India) | E1302 | Enalaprilat Dihydrate | 84680-54-6 | 250MG | ₹18700 | 2022-05-26 | Buy |
ENALAPRILAT DIHYDRATE Chemical Properties,Uses,Production
Description
Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril , an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC50 value of 5.8 nM in vitro.
Chemical Properties
White Solid
Definition
ChEBI: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients wi h nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.
ENALAPRILAT DIHYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| DR REDDYS LABORATORIES LTD | +91-40-49002900 | New Delhi, India | 201 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20361 | 58 | Inquiry |