NOOTKATONE
- CAS No.
- 4674-50-4
- Chemical Name:
- NOOTKATONE
- Synonyms
- NONANOL;（+）-Nootkatone;nootkartone;NOOTKATONE, NATURAL;4.beta.H,5.alpha.-Eremorphila-1(10)11-dien-2-one;(4R)-4,4a,5,6,7,8-Hexahydro-4,4aβ-dimethyl-6α-(1-methylethenyl)naphthalen-2(3H)-one;(4R,4aS,6R)-4,4a-Dimethyl-6-(prop-1-en-2-yl)-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one;2(3H)-Naphthalenone, 4,4a,5,6,7,8-hexahydro-4,4a-dimethyl-6-(1-methylethenyl)-, (4R,4aS,6R)-;FEMA 3166;Nootkatane
- CBNumber:
- CB3751288
- Molecular Formula:
- C15H22O
- Molecular Weight:
- 218.33
- MOL File:
- 4674-50-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 35-39 °C |
|---|---|
| Boiling point | 125°C 0,5mm |
| Density | 0,997 g/cm3 |
| FEMA | 3166 | NOOTKATONE |
| refractive index |
n |
| Flash point | 99°C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Pale Yellow |
| Odor | at 100.00 %. grapefruit peel citrus gardenia woody |
| Odor Type | citrus |
| optical activity | [α]20/D +182.0±5.0°, c = 1% in ethanol |
| biological source | synthetic |
| Water Solubility | Slightly soluble in ethanol and chloroform. Partly soluble in water. |
| JECFA Number | 1398 |
| BRN | 4676969 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | WTOYNNBCKUYIKC-UHFFFAOYSA-N |
| LogP | 3.84 |
| EPA Substance Registry System | 2(3H)-Naphthalenone, 4,4a,5,6,7,8-hexahydro-4,4a-dimethyl-6-(1-methylethenyl)-, (4R,4aS,6R)- (4674-50-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317 | |||||||||
| Precautionary statements | P280 | |||||||||
| Safety Statements | 23-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29142990 | |||||||||
| Hazardous Substances Data | 4674-50-4(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
NOOTKATONE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W316620 | Nootkatone ≥98%, FG | 4674-50-4 | 1SAMPLE-K | ₹7988.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W316620 | Nootkatone ≥98%, FG | 4674-50-4 | 25G | ₹26986.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W316620 | Nootkatone ≥98%, FG | 4674-50-4 | 100G | ₹103660.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 74437 | (+)-Nootkatone ≥99.0% (GC) | 4674-50-4 | 1G | ₹14018.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 74437 | (+)-Nootkatone ≥99.0% (GC) | 4674-50-4 | 2.5G | ₹18543.23 | 2022-06-14 | Buy |
NOOTKATONE Chemical Properties,Uses,Production
Description
Nootkatone has a pleasant taste. It may be prepared by oxidation of valencene (a sesquiterpene) with tertiary butyl chromate.
Chemical Properties
NOOTKATONE has been isolated from grapefruit peel and juice
and identified in other citrus oils as well. The commercially available product is a
colorless to yellowish liquid with a typical grapefruit odor.
Nootkatone can be prepared by oxidation of valencene, a sesquiterpene hydrocarbon
isolated from orange oils. The oxidation can be accomplished either by
chemical or by biotechnological methods.
Nootkatone is used for flavoring beverages.
Occurrence
Reported found in grapefruit oil and juice; traces are also reported found in the oils of bergamot, lemon, lime, orange and tangerine; also reported formed in canned orange juice on storage.
Uses
Nootkatone is an effective repellent/insecticide against mosquitos, and may repel bed bugs, head lice and other insects. Nootkatone in spray form has been shown as an effective repellent/insecticide against deer ticks and lone star ticks.
Preparation
By oxidation of valencene (a sesquiterpene) with tertiary butyl chromate.
Definition
ChEBI: A sesquiterpenoid that is 4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one which is substituted by methyl groups at positions 4 and 4a, and by an isopropenyl group at position 6 (the 4R,4aS,6R stereoisomer).
General Description
(+)-nootkatone, a bicyclic conjugated sesquiterpene ketone with a grapefruit-like flavor, is commonly used in fragrance, food, cosmetics and pharmaceutical industry. It can be synthesized from (+)-valencene via biotransformation. (+)-nootkatone is the active ingredient responsible for the antiplatelet effect of Cyperus rotundus, a well-known oriental traditional medicine. It also shows promising efficacy against Staphylococcus aureus biofilms.
NOOTKATONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6088 | 58 | Inquiry |
| P.P. Sheth Aromas Pvt., Ltd. | 91-22-27780900 | Maharashtra, India | 35 | 58 | Inquiry |
| Vishal Essential Oils & Chemicals | 08068441027Ext 388 | Delhi, India | 10 | 58 | Inquiry |
| Arpan Aromatics | 08048372666Ext 828 | Ahmedabad, India | 138 | 58 | Inquiry |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | China | 202 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | China | 8808 | 58 | Inquiry |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | China | 12809 | 58 | Inquiry |
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