Creatine ethyl ester hydrochloride

Creatine ethyl ester hydrochloride Structure
CAS No.
15366-32-2
Chemical Name:
Creatine ethyl ester hydrochloride
Synonyms
CREATINE ETHYL ESTER HCL(SH);CREATINE ETHYL ESTER HCL (P);CREATINE ETHYL ESTER HYDROCHLORIDE;Creatine ethyl ester hydrochloridel;Creatine ethyl ester hydrochloride[3];Ethyl N-carbamimidoyl-N-methylglycinate hyd;Ethyl 2-(1-Methylguanidino)acetate hydrochloride;ethyl N-carbamimidoyl-N-methylglycinate hydrochloride;Glycine, N-(aminoiminomethyl)-N-methyl-, ethyl ester,monohydrochloride;Glycine,N-(aMinoiMinoMethyl)-N-Methyl-, ethyl ester, hydrochloride (1:1)
CBNumber:
CB3825372
Molecular Formula:
C6H14ClN3O2
Molecular Weight:
195.65
MOL File:
15366-32-2.mol
Modify Date:
2024/7/2 9:33:31

Creatine ethyl ester hydrochloride Properties

Melting point 162-165°C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Creatine ethyl ester hydrochloride Chemical Properties,Uses,Production

Synthesis

Creatine ethyl ester hydrochloride is prepared by the reaction of ethanol and creatine. The specific synthesis steps are as follows:
Phosphorochloridic acid (2.0-2.5 equivalents to creatine) was added dropwise to a suspension of creatine in 10 mL of ethanol at 0° C. The reaction mixture was stirred for 15 min at 0° C. and the temperature then raised to 60° C. and stirred for 30 min. The reaction mixture was then cooled to provide 1.7 g of the hydrochloride salt of title compound (24) (73percent yield) as a white solid. 1H NMR (CD3OD, 400 MHz): δ 4.20-4.30 (m, 4H), 3.16(s, 3H, creatinine NCH3), 3.08 (s, 3H, CBE NCH3), 1.31 (d, J=6.8 Hz), (CBE/creatinine=9:1).
Creatine ethyl ester hydrochloride synthesis

Creatine ethyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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CREATINE ETHYL ESTER HYDROCHLORIDE CREATINE ETHYL ESTER HCL (P) Creatine ethyl ester hydrochloridel CREATINE ETHYL ESTER HCL(SH) Ethyl 2-(1-Methylguanidino)acetate hydrochloride Glycine,N-(aMinoiMinoMethyl)-N-Methyl-, ethyl ester, hydrochloride (1:1) Creatine ethyl ester hydrochloride[3] Ethyl N-carbamimidoyl-N-methylglycinate hyd Glycine, N-(aminoiminomethyl)-N-methyl-, ethyl ester,monohydrochloride ethyl N-carbamimidoyl-N-methylglycinate hydrochloride 15366-32-2 1960-7-14 15366-32-0 C6H14ClN3O2 C6H13N3O2ClH