alpha-Arbutin
![alpha-Arbutin Structure](CAS/GIF/84380-01-8.gif)
- CAS No.
- 84380-01-8
- Chemical Name:
- alpha-Arbutin
- Synonyms
- Alpha Arbutin Powder;Α-ARBUTIN;α-Arbutin;a-Arbutin;4-hydroquinone-alpha-d-glucopyranoside;(2R,3S,4S,5R,6S)-2-(HYDROXYMETHYL)-6-(4-HYDROXYPHENOXY)TETRAHYDROPYRAN-3,4,5-TRIOL;(2R,3S,4S,5R,6R)-2-(Hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol;LGB-AA;Alpha bear;alpha-arbutin
- CBNumber:
- CB3855311
- Molecular Formula:
- C12H16O7
- Molecular Weight:
- 272.25
- MOL File:
- 84380-01-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/2 20:38:39
Melting point | 195-196°C |
---|---|
Boiling point | 561.6±50.0 °C(Predicted) |
Density | 1.556±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 10.10±0.15(Predicted) |
color | White to Off-White |
BRN | 89675 |
InChI | InChI=1/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12+/s3 |
InChIKey | BJRNKVDFDLYUGJ-ZIQFBCGOSA-N |
SMILES | O(C1C=CC(O)=CC=1)[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O |&1:8,9,10,12,14,r| |
CAS DataBase Reference | 84380-01-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 2938.90.0000 | |||||||||
NFPA 704 |
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alpha-Arbutin price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 03338 | α-Arbutin analytical standard | 84380-01-8 | 100MG | ₹18499.93 | 2022-06-14 | Buy |
TCI Chemicals (India) | A3284 | α-Arbutin | 84380-01-8 | 5G | ₹3200 | 2022-05-26 | Buy |
TCI Chemicals (India) | A3284 | α-Arbutin | 84380-01-8 | 25G | ₹8800 | 2022-05-26 | Buy |
alpha-Arbutin Chemical Properties,Uses,Production
Description
Arbutin is naturally found in plant sources such as Bearberry, Cranberry and Mulberry, which essentially prevents the formation of melanin (the pigment that creates skin colour). The chemically synthesised version of this plant extract is known as Alpha Arbutin which is used as a topical skin brightening agent to treat sun spots, pigmentation and scars caused by sun damage and breakouts. It also has antioxidant properties, which protect the skin from potential sun damage. Along with Retinol, it is a fairly common ingredient in anti-ageing products to treat age spots, fine lines and wrinkles.
Chemical Properties
alpha-Arbutin is White Solid
Uses
alpha-Arbutin is a component used in the skin-whitening cosmetics.
Definition
Alpha arbutin, also called Hydroquinone β-D-glucopyranoside, is a naturally occurring antioxidant and skin brightener that is naturally found in the bearberry plant. It reduces melanin formation, improving the appearance of age spots, freckles, melasma, and post-inflammatory pigmentation.
Definition
Arbutin is the best as compared to vitamin c because it has fewer side effects and more benefits like reducing dark spots, age spots, ageing, etc. Arbutin gives quicker results than vitamin C. Arbutin acts as hydroquinone, which means it has depigmenting factors. Vitamin C is not easily absorbed into the skin, whereas arbutin absorbs quickly into the skin.
benefits
Ensures an even skin tone after only one month;Reduces the degree of skin tanning after UV exposure;Helps to minimize the appearance of liver spots.
Biological Functions
Alpha arbutin acts as a tyrosinase competitive inhibitor and also slows melanosome maturation (the organelles that synthesize and store melanin or pigment).3 This is significant because it works on two different mechanisms of pigmentation. Melanin is derived from the amino acid tyrosine and this conversion is regulated by the enzyme tyrosinase. Alpha arbutin is similar in structure to tyrosine, which fits into tyrosinase, needed for melanogenesis. This means that alpha arbutin is reversibly competing with tyrosine for a spot on the enzyme and not inhibiting cell viability, so therefore is not cytotoxic. By targeting tyrosinase, the rate-limiting enzyme in melanin formation, as well as slowing production of the organelles that produce melanin, alpha arbutin is a potent skin brightening agent.
General Description
α-Arbutin is a glycosylated hydroquinone and an anomer of naturally occurring arbutin. It is a potent inhibitor of tyrosinase, a vital enzyme involved in epidermal melanin biosynthesis. α-Arbutin finds extensive application as a powerful skin-lightening agent in cosmetic industries.
Mechanism of action
Alpha arbutin is frequently marketed as a safer alternative to hydroquinone (a popular skin-lightening ingredient that has been banned in Europe and Australia). It has similar results in brightening skin but without the dangerous bleaching process. Instead, it reduces skin’s pigment production by suppressing the enzymes that stimulate melanin. This also slows down the process by which UV light causes pigmentation, so it both prevents and treats pigmentation issues.
Side effects
Alpha arbutin is an active compound. Using too many active agents together can cause harshness to your skin.
For sensitive skin, using too much product containing alpha arbutin can cause a burning sensation on your face or skin.
Using moisturisers just after applying alpha arbutin cream or gel may not work well on your skin. It is a light compound which does not absorb well into the skin if topped over a moisturiser.
Alpha arbutin side effects occur when applied on cracked skin. It is suitable for topical use but when it comes in contact with an exposed wound, it causes unbearable irritation.
alpha-Arbutin Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
Kiama Research Labs | 08046033202 | Gujarat, India | 26 | 58 | Inquiry |
Kaveri Bio Technology | 08048985058 | Delhi, India | 14 | 58 | Inquiry |
A R Enterprises | 08048250207Ext 239 | Mumbai, India | 3 | 58 | Inquiry |
Real Herbal & Chemicals | 08046061717 | Delhi, India | 21 | 58 | Inquiry |
Bodar Industries | 08048611019 | Gujarat, India | 42 | 58 | Inquiry |
Purenso Global | 08047632195 | Madhya Pradesh, India | 44 | 58 | Inquiry |
Supplier | Advantage |
---|---|
Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
A.J Chemicals | 58 |
CLEARSYNTH LABS LTD. | 58 |
CHEMSWORTH | 30 |
Kiama Research Labs | 58 |
Kaveri Bio Technology | 58 |
A R Enterprises | 58 |
Real Herbal & Chemicals | 58 |
Bodar Industries | 58 |
Purenso Global | 58 |
Related articles
- Benefits and side effects of alpha-Arbutin on the skin
- alpha-Arbutin is a hydroquinone derivative. It is obtained mainly by enzymatic synthesis of hydroquinone.
- Jun 12,2024
- The brief introduction of alpha-Arbutin
- Alpha arbutin works by slowly releasing hydroquinone over time, inhibiting tyrosinase, the key enzyme responsible for melanin,....
- Apr 17,2024
- alpha-Arbutin: A Review of its Application as a Skin Lightening Agent
- alpha-Arbutin is a hydroquinone glycoside compound existing in bear fruit, bilberry and other plants.
- May 24,2023
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