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guanidine

guanidine Structure
CAS No.
113-00-8
Chemical Name:
guanidine
Synonyms
imidourea;Carbamidine;carbamamidine;Guanidine 98%;Guanidinebase;Diaminomethanimine;Ribavirin Impurity T;Guanidine, free base;Metformin Impurity 33;Metformin Impurity 33 Monomer
CBNumber:
CB3874769
Molecular Formula:
CH5N3
Molecular Weight:
59.07
MOL File:
113-00-8.mol
MSDS File:
SDS
Modify Date:
2023/10/19 14:49:32
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guanidine Properties

Melting point ~50°
Boiling point 82.3°C (rough estimate)
Density 1.6000 (rough estimate)
refractive index 1.5950 (estimate)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
pka pKa ~12.5(at 25℃)
form Solid
color White
EPA Substance Registry System Guanidine (113-00-8)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H319-H410
Precautionary statements  P264-P273-P280-P337+P313-P391-P501
RIDADR  1759
HazardClass  8
PackingGroup  II
Toxicity LD50 i.p. in mice: 350 mg/kg (Podlesnaya)

guanidine Chemical Properties,Uses,Production

Chemical Properties

Colorless crystals. Soluble inwater and alcohol. Combustible. Guanidine is a strong monobasic Bronsted base, which absorbs water and carbon dioxide from the air and forms strongly alkaline solutions with water and alcohols; the pH of a 20 wt % aqueous solution is ca. 13.5 (25 ℃). In aqueous solution at elevated temperature guanidine is hydrolyzed to urea; airtight alcohol solutions are stable. Guanidine is infinitely soluble in water, ethanol, methanol, and dimethylformamide.

Uses

Guanidine is an intermediate in synthesizing N-Formylguanidine (F700505), which is used in the preparation of Amiloride (A578700), a sodium channel blocker used as a diuretic drug.

Production Methods

Guanidine is formed (1) by heating ammonium thiocyanate to 180 °C, (2) by ammonolysis of orthocarbonates, C(OC2H5)4 + 3NH3 → (NH2)2C=NH + 4C2H5OH, (3) by ammonolysis of chloropicrin, Cl3CNO2 + 7NH3 → NH2)2 C=NH + 3NH4Cl + N2 + 3H2O, (4) by ammonolysis of cyanogen chloride, ClCN + NH3 → ClC(NH2)=NH → HN=C=NH → (NH2)2 C=NH.
Guanidine forms salts with acids, e.g., guanidine nitrate, HNC(NH2)2 · HNO3. By heating at 120 °C for several hours, a mixture of ammonium thiocyanate and dicyanodiamide, guanidine thiocyanate solution is obtained by extracting with water. Treating guanidine with a mixture of nitric and sulfuric acids forms nitroguanidine which is reduced by zinc and acetic acid to aminoguanidine.
By treating aminoguanidine (1) with dilute acid or alkali, there is obtained, first, semicarbazide, finally hydrazine; (2) with nitrous acid, diazoguanidine which is decomposed by alkali into alkali azide (e.g., NaN3) plus cyanamide (H2N·CN) plus water.

Agricultural Uses

Carbamidine is another name for guanidine. It is a crystalline basic compound related to urea. It forms a number of salts which are used as fertilizers. Guanidine phosphate is an example.

Purification Methods

Crystallise it from water/EtOH under nitrogen. It is very deliquescent and absorbs CO2 from the air readily. [Jones Trans Faraday Soc 55 524 1959, Beilstein 3 H 82, 3 I 39, 3 II 69, 3 III 154, 3 IV 148.]

guanidine Preparation Products And Raw materials

Raw materials

Calcium cyanamide Ammonium iodide

Preparation Products

Cyanamide Pentobarbital Isocytosine 2,4-DIAMINO-6-ETHOXYPYRIMIDINE 2-amino-1,5-dihydro-4H-imidazol-4-one
2-AMINO-5-CARBOETHOXY-4-HYDROXYPYRIMIDINE Pemoline 2-Hydroxypropanoic acid 4-Pyrimidinol 2-Amino-6-methyl-4-pyrimidinol
2-Amino-4,6-dimethylpyrimidine
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guanidine Suppliers

Global( 61)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Triveni chemicals 08048762458 New Delhi, India 6093 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21676 55 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9338 55 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9626 58 Inquiry
CD Chemical Group Limited +8615986615575 China 20356 58 Inquiry
Shaanxi Didu New Materials Co. Ltd +86-89586680 +86-13289823923 China 9003 58 Inquiry
Supplier Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Triveni chemicals 58
Pharma Affiliates 58
Henan Tianfu Chemical Co.,Ltd. 55
Hangzhou FandaChem Co.,Ltd. 55
career henan chemical co 58
AFINE CHEMICALS LIMITED 58
Finetech Industry Limited 58
CD Chemical Group Limited 58
Shaanxi Didu New Materials Co. Ltd 58

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carbamamidine Diaminomethanimine Guanidinebase Ribavirin Impurity T Guanidine 98% Guanidine, free base tert-Butyl 3-[(4-chlorobenzyl)amino]propanoate Metformin Impurity 33 imidourea Carbamidine Metformin Impurity 33 Monomer 113-00-8 Pharmaceutical Intermediates