niridazole
- CAS No.
- 61-57-4
- Chemical Name:
- niridazole
- Synonyms
- BA32644;Ambilhar;niridazole;NSC-136947;Nitrothiamidazole;1-(5-NITRO-2-THIAZOLYL)-2-IMIDAZOLIDINONE;1-(5-nitrothiazol-2-yl)imidazolidin-2-one;2-Imidazolidinone, 1-(5-nitro-2-thiazolyl)-;1-(5-nitro-1,3-thiazol-2-yl)imidazolidin-2-one
- CBNumber:
- CB3896840
- Molecular Formula:
- C6H6N4O3S
- Molecular Weight:
- 214.204
- MOL File:
- 61-57-4.mol
- Modify Date:
- 2024/3/19 15:37:51
| Melting point | 260-262° |
|---|---|
| Density | 1.561 (estimate) |
| refractive index | 1.6200 (estimate) |
| form | solid |
| pka | 12.73±0.20(Predicted) |
| color | Yellow crystals from DMF/MeOH |
| Water Solubility | 0.13g/L(25 ºC) |
| IARC | 2B (Vol. 13, Sup 7) 1987 |
| EPA Substance Registry System | Niridazole (61-57-4) |
SAFETY
Risk and Safety Statements
| Toxicity | TDLo orl-rat: 8 g/kg/90W-I:NEO CALEDQ 4,305,78 orl-rat LD50:900 mg/kg FAZMAE 17,108,73 |
|---|
niridazole Chemical Properties,Uses,Production
Uses
Antischistosomal.
Pharmacology
Niridazole exhibits schistosomicide and amebicidal action. The mechanism of action is not
known. It seems likely that it is concentrated in the parasite organism, which causes inhibition of phosphorylase activation, which is expressed in the depletion of glycogen reserves.
It also may inhibit spermatogenesis of parasites by affecting the production of eggs. It is
used for diseases caused by Dracunculus meddinesis, as well as Shistosoma haematobium
and Shistosoma mansoni. It belongs to a group of tertiary drugs and is used only in the
absence of the drug of choice. Synonyms of this drug are ambilhar and others.
Safety Profile
Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. Used as an amoebicide and schistosomicidal agent.
niridazole Preparation Products And Raw materials
Raw materials
Preparation Products
niridazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24016 | 58 | Inquiry |
| Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd | (852)2541 2772 | China | 6214 | 58 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
| Shanghai Hao Zhun Biological Technology Co., Ltd. | 15800340161 | CHINA | 6846 | 58 | Inquiry |
| Alfa Chemistry | 1-516-6625404 | United States | 9171 | 60 | Inquiry |
61-57-4(niridazole )Related Search:
1of2
chevron_right