2-Amino-5-nitrothiazole
- CAS No.
- 121-66-4
- Chemical Name:
- 2-Amino-5-nitrothiazole
- Synonyms
- 5-Nitrothiazol-2-amine;ENHEPTYNE;Nitazoxanide Related Compound A (25 mg) (2-Amino-5-nitrothiazole);NSC 4;ENHEPTIN;entramin;AKOS 203;ENTRAMINE;enheptint;enheptin-t
- CBNumber:
- CB5143401
- Molecular Formula:
- C3H3N3O2S
- Molecular Weight:
- 145.14
- MOL File:
- 121-66-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/29 15:17:36
| Melting point | 195-200 °C (dec.) (lit.) |
|---|---|
| Boiling point | 345.1±15.0 °C(Predicted) |
| Density | 1.583 (estimate) |
| refractive index | 1.6740 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | 95% ethanol: soluble1g/150g at 20°C |
| form | Powder |
| pka | 1.26±0.10(Predicted) |
| color | Yellow |
| Water Solubility | <0.1 g/100 mL at 20 ºC |
| Sensitive | Light Sensitive |
| Merck | 14,457 |
| BRN | 126797 |
| Stability | Stable. Incompatible with strong acids, strong oxidizing agents, acid chlorides, acid anhydrides. |
| InChIKey | MIHADVKEHAFNPG-UHFFFAOYSA-N |
| CAS DataBase Reference | 121-66-4(CAS DataBase Reference) |
| IARC | 3 (Vol. 31, Sup 7) 1987 |
| EPA Substance Registry System | 2-Amino-5-nitrothiazole (121-66-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XJ2800000 | |||||||||
| F | 8 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29341000 | |||||||||
| NFPA 704 |
|
2-Amino-5-nitrothiazole price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 133507 | 2-Amino-5-nitrothiazole 97% | 121-66-4 | 25G | ₹2100.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2889 | Nitazoxanide Related Compound A pharmaceutical secondary standard, certified reference material | 121-66-4 | 50MG | ₹46460.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 133507 | 2-Amino-5-nitrothiazole 97% | 121-66-4 | 100G | ₹5564.05 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A0381 | 2-Amino-5-nitrothiazole | 121-66-4 | 25G | ₹4700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A0381 | 2-Amino-5-nitrothiazole | 121-66-4 | 500G | ₹66300 | 2022-05-26 | Buy |
2-Amino-5-nitrothiazole Chemical Properties,Uses,Production
Chemical Properties
greenish yellow, to orange or brown powder
Uses
2-Amino-5-nitrothiazole was used as diazo component in the synthesis of monoazo disperse dyes. It was used as matrix during matrix-assisted laser desorption/ionization time-of-flight mass spectrometric study of oligonucleotide and protein.
Production Methods
Early production of 2-Amino-5-nitrothiazole was based on nitration of 2-acetylaminothiazole and careful hydrolysis. Direct nitration of 2-aminothiazole gives a cleaner product and is best achieved by adding 2-aminothiazole nitrate [57530-25-3] to concentrated sulfuric acid at 0 – 10 ℃. This process and the nitration of o-anisidine are the only large-scale processes based on rearrangement of an amine nitrate, and both are potentially hazardous due to the possibility of runaway exothermic reactions.
General Description
Greenish-yellow to orange-yellow fluffy powder or a brown chunky powder. Slightly bitter taste. Used as a veterinary medicine.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
2-Amino-5-nitrothiazole may be sensitive to light. Incompatible with nitric acid and sulfuric acid. Also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. A preparative hazard .
Fire Hazard
Flash point data for 2-Amino-5-nitrothiazole are not available. 2-Amino-5-nitrothiazole is probably combustible.
Safety Profile
Poison by intraperitoneal route. Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SO,. Incompatible with HNO3 and H2SO4. An antiprotozoal agent.
Potential Exposure
2-Amino-5-nitrothiazole is a synthetic veterinary antiprotozoal agent used since 1950 to treat farm fowl and pigeons. It is also used as an intermediate in manufacturing a group of dyes known as disperse azo dyes. It is not known to occur as a natural product. People may be exposed to 2-amino-5-nitrothiazole through contact with birds treated with the drug, releases from poultry farms, and occupational exposures in the dye industry.
2-Amino-5-nitrothiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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