nafiverine
- CAS No.
- 5061-22-3
- Chemical Name:
- nafiverine
- Synonyms
- DA-914;nafiverine;Nafiverina;Nafiverinum;Naftimepezine;UNII-WLT400RC9Q;EINECS 225-766-5;Bis(α-methyl-1-naphthaleneacetic acid)2,2'-(1,4-piperazinediyl)bisethyl ester;1-Naphthaleneacetic acid, α-methyl-, 1,1'-(1,4-piperazinediyldi-2,1-ethanediyl) ester;2-[4-[2-(2-naphthalen-1-ylpropanoyloxy)ethyl]piperazin-1-yl]ethyl 2-naphthalen-1-ylpropanoate
- CBNumber:
- CB3907263
- Molecular Formula:
- C34H38N2O4
- Molecular Weight:
- 538.684
- MOL File:
- 5061-22-3.mol
- Modify Date:
- 2023/5/4 17:34:39
nafiverine Chemical Properties,Uses,Production
Originator
Naftidan,De Angeli,Italy,1969
Manufacturing Process
15 grams of α-methyl-1-naphthylacetic acid were refluxed with 50 ml of thionyl chloride during 3 hours. The excess thionyl chloride was removed under reduced pressure and the product was also isolated by distillation under reduced pressure. Yield: 15.6 grams (96%). The α-methyl-1-naphthyl acetyl chloride boils at 120° to 124°C. 1.76 grams of N,N'-di-(β-hydroxyethyl)- piperazine, 1.9 grams of sodium bicarbonate and 4.45 grams of α-methyl-1- naphthyl acetyl chloride in 30 ml of anhydrous acetonitrile were refluxed with stirring during 5 hours. After cooling the mixture was filtered and the acetonitrile evaporated off under reduced pressure. 5.2 grams of crude ester were obtained. The hydrochloride, melting at 220° to 221°C, may be prepared by dissolving the ester in absolute ethanol and treating the solution with anhydrous gaseous hydrogen chloride.
Therapeutic Function
Spasmolytic
nafiverine Preparation Products And Raw materials
nafiverine Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | China | 2417 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
TargetMol Chemicals Inc. | 4008200310 | China | 24017 | 58 | Inquiry |
Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 | China | 10011 | 58 | Inquiry |