Forodesine

CAS No.: 209799-67-7

Chemical Name:: Forodesine

Synonyms: Fodosine;Forodesine;Isopamphos;Immucillin-H;BCX-1777 freebase;FORODESINE FODOSINE;(1S)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride;(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H;4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-;7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

CBNumber:: CB41120376

Molecular Formula:: C11H14N4O4

Molecular Weight:: 266.25

MOL File:: 209799-67-7.mol

Modify Date:: 2024/7/2 8:55:07

Request For Quotation

Forodesine Properties

Boiling point	613.5±65.0 °C(Predicted)
Density	2.01
storage temp.	Hygroscopic, Refrigerator, under inert atmosphere
solubility	PBS (pH 7.2): 5 mg/ml
form	A crystalline solid
pka	13.88±0.70(Predicted)
color	Light brown to gray

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

NFPA 704

	0
2		0

Forodesine Chemical Properties,Uses,Production

Description

Forodesine is a purine nucleoside analog and purine nucleoside phosphorylase (PNP) inhibitor (IC₅₀s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively). It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC₅₀s = <0.1-0.38 μM) in the presence, but not absence, of 2’-deoxyguanosine (dGuo). Forodesine inhibits proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells. In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).

Uses

Treatment of T-Cell malignancies such as acute lymphoblastic leukemia (ALL) and cutaneous T-cell lymphoma (CTCL) Fodosine.

Forodesine Preparation Products And Raw materials

Raw materials

Preparation Products

Forodesine Suppliers

Global( 48)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49403	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	China	9316	58	Inquiry
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	China	9980	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	China	25363	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
Suzhou ARTK Medchem Co., Ltd.	+86-512-68323658 +86-18168183658	China	39010	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Baoji Guokang Bio-Technology Co., Ltd.	58
NewCan Biotech Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Aladdin Scientific	58
Suzhou ARTK Medchem Co., Ltd.	58

209799-67-7(Forodesine)Related Search:

Polyvinylpyrrolidone Crospovidone N-Methyl-2-pyrrolidone N-Vinyl-2-pyrrolidone Povidone iodine

1,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE Forodesine METHYL-2-PYRROLIDONE

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4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro- Forodesine 7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one Fodosine Immucillin-H (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H FORODESINE FODOSINE 4H-Pyrrolo[3,2-d]pyriMidin-4-one,7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-2-pyrrolidinyl]-3,5-dihydro- BCX-1777 freebase Isopamphos (1S)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride 7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one 209799-67-7