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N-Desmethyl Imatinib

CAS No.: 404844-02-6

Chemical Name:: N-Desmethyl Imatinib

Synonyms: N-DesmethyL;Imatinib EP Impurity C;CGP-74588;STI 509-00;Norimatinib;no mesylate;Imatinib Imp.F;N-methylimatinib;DesMethyl IMatinib;Imatinib Impurity F

CBNumber:: CB41176575

Molecular Formula:: C28H29N7O

Molecular Weight:: 479.58

MOL File:: 404844-02-6.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:07

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N-Desmethyl Imatinib Properties

Melting point	99-101°C
Density	1.268±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml
form	A lyophilized solid
pka	13.28±0.70(Predicted)
color	Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H302-H341-H351-H360-H362

Precautionary statements

P201-P202-P260-P263-P264-P270-P280-P301+P312-P330-P308+P313-P405-P501

Safety Statements

24/25

HS Code

29339900

NFPA 704

	0
2		0

N-Desmethyl Imatinib Chemical Properties,Uses,Production

Description

N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC₅₀ = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.

Chemical Properties

Off-White to Pale-Yellow Solid

Uses

N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

N-Desmethyl Imatinib Preparation Products And Raw materials

Raw materials

Preparation Products

N-Desmethyl Imatinib Suppliers

Global( 195)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
VSK LIFE SCIENCES PRIVATE LIMITED	+91 7995529789	Hyderabad, India	220	58	Inquiry
Varanous Labs Pvt Ltd	+91-7036248882 +91-7036248882	Hyderabad, India	1541	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21669	55	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9337	55	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29898	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry

Supplier	Advantage
VSK LIFE SCIENCES PRIVATE LIMITED	58
Varanous Labs Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
CLEARSYNTH LABS LTD.	58
SynZeal Research Pvt Ltd	58
Pharma Affiliates	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
BOC Sciences	58

N-Desmethyl Imatinib Spectrum

N-Desmethyl Imatinib(404844-02-6)¹HNMR

404844-02-6(N-Desmethyl Imatinib)Related Search:

Imatinib 1,4-Bis-[4-[4-Methyl-3-[[4-(pyridin-3-yl)pyriMidin-2-yl]aMino]phenyl]carbaMoyl]benzylpiperazine iMatinib related substance B 2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID Imatinib (Piperidine)-N-oxide

4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Guanidine, N-(2-methyl-3-nitrophenyl)- Imatinib Impurity 7 N-DESMETHYL IMATINIB 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide

IMatinib Para-diaMinoMethylbenzene Imatinib Meta-methyl-piperazine Impurity iMatinib related substance C 3-Acetylpyridine Imatinib EP Impurity J

N-(3-GUANIDINO-4-METHYLPHENYL)-4-(METHYLPIPERAZINE-1-YL-METHYL)BENZAMIDE Imatinib EP Impurity D Imatinib (Pyridine)-N-oxide

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CGP-74588 N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide Norimatinib STI 509-00 N-{4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4-(piperazin-1-ylmethyl)benzamide DesMethyl IMatinib DesMethyl IMatinib-d8 iMatinib related substance A IMatinib N-DesMethyl IMpurity Imatinib Impurity F Imatinib metabolite N-Desmethyl Imatinib Imatinib impurity 6/Imatinib EP Impurity C/N-Desmethyl Imatinib/N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide Benzamide,N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)- IMATINIB METABOLITE N-DESMETHYL IMATINIB (N-DESMETHYL IMATINIB) Imatinib EP Impurity C (N-Desmethyl Imatinib) Imatinib Imp.F Imatinib Impurity 6(Imatinib EP Impurity C) N-Desmethyl Imatinib Impurity no mesylate Imatinib Impurity 6（EP-C） Imatinib Impurity C (Imatinib (Piperazine)-N1- Oxide) (crude) Imatinib Impurity C (Imatinib (Piperidine)-N4- Oxide) Imatinib EP Impurity C (Imatinib N-Desmethyl Impurity) N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4... Desmethyl imatinib D4Q: What is Desmethyl imatinib D4 Q: What is the CAS Number of Desmethyl imatinib D4 Q: What is the storage condition of Desmethyl imatinib D4 Q: What are the applications of Desmethyl imatinib D4 Imatinib N-Desmethyl ImpurityQ: What is Imatinib N-Desmethyl Impurity Q: What is the CAS Number of Imatinib N-Desmethyl Impurity Q: What is the storage condition of Imatinib N-Desmethyl Impurity Q: What are the applications of Imatinib N-Desmethyl Impurity Imatinib EP Impurity C N-DesmethyL N-methylimatinib Inhibitor,N Desmethyl imatinib,v-Abl,PDGFR,inhibit,NDesmethyl imatinib,Drug Metabolite,Imatinib,N-Desmethyl imatinib,c-Kit N-Desmethyl lmatinib 404844-02-6 C28H29N7O Metabolite Reference Standard Isotopically Labeled Pharmaceutical Reference Standard Intermediates & Fine Chemicals Metabolites Pharmaceuticals Tyrosine Kinase Inhibitors Various Metabolites and Impurities