ChemicalBook > Product Catalog >API >Antineoplastic agents >Tinib Antineoplastic drugs >N-Desmethyl Imatinib
N-Desmethyl Imatinib
- CAS No.
- 404844-02-6
- Chemical Name:
- N-Desmethyl Imatinib
- Synonyms
- N-DesmethyL;Imatinib EP Impurity C;CGP-74588;STI 509-00;Norimatinib;no mesylate;Imatinib Imp.F;N-methylimatinib;DesMethyl IMatinib;Imatinib Impurity F
- CBNumber:
- CB41176575
- Molecular Formula:
- C28H29N7O
- Molecular Weight:
- 479.58
- MOL File:
- 404844-02-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 99-101°C |
|---|---|
| Density | 1.268±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml |
| form | A lyophilized solid |
| pka | 13.28±0.70(Predicted) |
| color | Light yellow to yellow |
| biological source | synthetic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H341-H351-H360-H362 | |||||||||
| Precautionary statements | P201-P202-P260-P263-P264-P270-P280-P301+P312-P330-P308+P313-P405-P501 | |||||||||
| Safety Statements | 24/25 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
N-Desmethyl Imatinib Chemical Properties,Uses,Production
Description
N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC50 = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.
Chemical Properties
Off-White to Pale-Yellow Solid
Uses
N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.
N-Desmethyl Imatinib Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 213)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| VSK LIFE SCIENCES PRIVATE LIMITED | +91 7995529789 | Hyderabad, India | 220 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1537 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6514 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21628 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29858 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | CHINA | 1319 | 58 | Inquiry |
404844-02-6(N-Desmethyl Imatinib)Related Search:
Imatinib
1,4-Bis-[4-[4-Methyl-3-[[4-(pyridin-3-yl)pyriMidin-2-yl]aMino]phenyl]carbaMoyl]benzylpiperazine
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2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID
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4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
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1of4
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CGP-74588
N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide
Norimatinib
STI 509-00
N-{4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4-(piperazin-1-ylmethyl)benzamide
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DesMethyl IMatinib-d8
iMatinib related substance A
IMatinib N-DesMethyl IMpurity
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Imatinib metabolite N-Desmethyl Imatinib
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Benzamide,N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-
IMATINIB METABOLITE N-DESMETHYL IMATINIB (N-DESMETHYL IMATINIB)
Imatinib EP Impurity C (N-Desmethyl Imatinib)
Imatinib Imp.F
Imatinib Impurity 6(Imatinib EP Impurity C)
N-Desmethyl Imatinib Impurity
no mesylate
Imatinib Impurity 6（EP-C）
Imatinib Impurity C (Imatinib (Piperazine)-N1- Oxide) (crude)
Imatinib Impurity C (Imatinib (Piperidine)-N4- Oxide)
Imatinib EP Impurity C (Imatinib N-Desmethyl Impurity)
N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4...
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N-Demethylimatinib(Impurity)
404844-02-6
C28H29N7O
Metabolite Reference Standard
Isotopically Labeled Pharmaceutical Reference Standard
Intermediates & Fine Chemicals
Metabolites
Pharmaceuticals
Tyrosine Kinase Inhibitors
Various Metabolites and Impurities