3-Acetylpyridine
- CAS No.
- 350-03-8
- Chemical Name:
- 3-Acetylpyridine
- Synonyms
- 3-Acetylpiridine;methylpyridylketone;1-(3-PYRIDINYL)ETHANONE;Ethanone,1-(3-pyridinyl)-;NSC 761;FEMA 3424;Imatinib-int A;3-ActylPyridine;3-ACETOPYRIDINE;3-ACETYLPYRIDNE
- CBNumber:
- CB9286704
- Molecular Formula:
- C7H7NO
- Molecular Weight:
- 121.14
- MOL File:
- 350-03-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 15:15:06
| Melting point | 11-13 °C (lit.) |
|---|---|
| Boiling point | 220 °C (lit.) |
| Density | 1.102 g/mL at 25 °C (lit.) |
| vapor pressure | 0.3Pa at 20℃ |
| FEMA | 3424 | 3-ACETYLPYRIDINE |
| refractive index |
n |
| Flash point | 302 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | pK1: 3.256(+1) (25°C) |
| form | Liquid |
| color | Clear colorless to yellow |
| Specific Gravity | 1.102 |
| PH | 6.5-7.5 (H2O, 20℃) |
| Odor | at 1.00 % in dipropylene glycol. sweet nutty dry hawthorn phenolic woody popcorn |
| Odor Type | nutty |
| Water Solubility | SOLUBLE IN HOT WATER |
| Merck | 14,6116 |
| JECFA Number | 1316 |
| BRN | 107751 |
| InChIKey | WEGYGNROSJDEIW-UHFFFAOYSA-N |
| LogP | 0.34 at 13℃ |
| CAS DataBase Reference | 350-03-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanone, 1-(3-pyridinyl)-(350-03-8) |
| EPA Substance Registry System | Ethanone, 1-(3-pyridinyl)- (350-03-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P310-P302+P352-P332+P313 | |||||||||
| Hazard Codes | T,Xi,Xn | |||||||||
| Risk Statements | 25-36/38-36/37/38-20/21/22 | |||||||||
| Safety Statements | 45-37/39-28A-26-36 | |||||||||
| RIDADR | UN 2810 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | OB5425000 | |||||||||
| F | 8-10 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29333999 | |||||||||
| Toxicity | LD50 orl-rat: 46 mg/kg JACTDZ 1,681,92 | |||||||||
| NFPA 704 |
|
3-Acetylpyridine price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W342408 | 3-Acetylpyridine ≥98%, FG | 350-03-8 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W342408 | 3-Acetylpyridine ≥98%, FG | 350-03-8 | 100G | ₹12145.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W342408 | 3-Acetylpyridine ≥98%, FG | 350-03-8 | 1KG | ₹51158.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W342408 | 3-Acetylpyridine ≥98%, FG | 350-03-8 | 5KG | ₹170526.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A21207 | 3-Acetylpyridine 98% | 350-03-8 | 10G | ₹2121.7 | 2022-06-14 | Buy |
3-Acetylpyridine Chemical Properties,Uses,Production
Chemical Properties
clear colorless to yellow liquid
Occurrence
Reported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.
Uses
3-Acetylpyridine used as an intermediate for the synthesis of risedronate sodium, inhibitor of bone resorption. It is also used in perfumery.
Preparation
Dry distillation of calcium nicotinate with calcium acetate.
Definition
It is a nicotinic acidantagonist.
Production Methods
Produced from Ethyl nicotinate and Ethyl acetoacetate, in principle by hydrolysis of Aceto acetylpyridine.
Safety Profile
Poison by ingestion. Moderately toxic by intraperitoneal routeMutation data reported. A flammable liquid. When heated to decomposition emits toxic fumes of NOx,. See also KETONES
Purification Methods
It is purified by dissolving in HCl, extracting with Et2O to remove the possible impurity of nicotinic acid, basified with NaOH and extracted with Et2O. The dried extract is filtered, evaporated and the residual oil is distilled. If the NMR spectrum indicates further impurities, then convert it to the phenylhydrazone (m 137o, yellow needles from EtOH). This is hydrolysed with HCl [Engler & Kiby Chem Ber 22 597 1889], the phenylhydrazine HCl is removed by filtration, NaNO2 is added, the solution is basified with aqueous NaOH and extracted with Et2O as before and distilled at atmospheric pressure to give 3-acetylpyridine as a colourless oil. Purification can also be achieved by shaking with 50% aqueous KOH, extracting with Et2O, drying the extract and distilling it at atmospheric pressure or in vacuo. [Kloetzel & Chubb J Am Chem Soc 79 4226 1957.] The hydrochloride has m 180-181o (from MeOH/EtOH), the picrate has m 133.8-134.8o (from H2O), and the phenylhydrazone has m 137o (129-130o)(needles, from EtOH) [Webb & Webb J Am Chem Soc 71 2285 1949]. The ketoxime has m 112o (from EtOH or *C6H6). [Strong & McElvain J Am Chem Soc 55 816 1933, Kolloff & Hunter J Am Chem Soc 63 490 1941, Beilstein 21/7 V 394.]
3-Acetylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Advantage |
|---|---|
| Terma Medicare India Pvt.,Ltd | 58 |
| BTC pharm India | 58 |
| GLR Innovations | 58 |
| Vital synthetics | 58 |
| sgtlifesciences | 58 |
| Mekong pharmaceuticals pvt ltd | 58 |
| Real Chemsys Products Pvt Limited | 58 |
| DSN Labs | 58 |
| Sintilla Medcoms Pvt Ltd | 58 |
| Dr. Silviu Pharmachem Pvt., Ltd. | 58 |
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