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4-(Pyridin-3-yl)pyrimidin-2-amine

CAS No.: 66521-66-2

Chemical Name:: 4-(Pyridin-3-yl)pyrimidin-2-amine

Synonyms: 4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE;BUTTPARK 41\09-83;)-2-pyrimidine amine;4-(3-Pyridyl)-2-pyrimidinamine;Nilotinib 3-Pyridinyl Impurity;4-(3-Pyridyl)-2-pyrimidineamine;2-Amino-4-(3-pyridyl)pyrimidine;4-(3-PYRIDINYL)-2-PYRIMIDINAMINE;4-(3-Pyridinyl)-2-aminopyrimidine;2-PyriMidinaMine,4-(3-pyridinyl)-

CBNumber:: CB8228031

Molecular Formula:: C9H8N4

Molecular Weight:: 172.19

MOL File:: 66521-66-2.mol

MSDS File:: SDS

Modify Date:: 2024/1/17 10:48:25

Request For Quotation

4-(Pyridin-3-yl)pyrimidin-2-amine Properties

Melting point	189-191 °C
Boiling point	439.9±37.0 °C(Predicted)
Density	1.259±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	2.76±0.10(Predicted)
color	Off-White to Pale Yellow
InChI	InChI=1S/C9H8N4/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H,(H2,10,12,13)
InChIKey	LQHQKYWYKPLKCH-UHFFFAOYSA-N
SMILES	C1(N)=NC=CC(C2=CC=CN=C2)=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes

Risk Statements

25-20/21/22

Safety Statements

45-36/37

HS Code

29339900

NFPA 704

	0
2		0

4-(Pyridin-3-yl)pyrimidin-2-amine price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemicals (India)	P2666	4-(Pyridin-3-yl)pyrimidin-2-amine min. 98.0 %	66521-66-2	1G	₹4200	2022-05-26	Buy
TCI Chemicals (India)	P2666	4-(Pyridin-3-yl)pyrimidin-2-amine min. 98.0 %	66521-66-2	5G	₹19400	2022-05-26	Buy

Product number	Packaging	Price	Buy
P2666	1G	₹4200	Buy
P2666	5G	₹19400	Buy

4-(Pyridin-3-yl)pyrimidin-2-amine Chemical Properties,Uses,Production

Chemical Properties

White to off-white or brown solid.

Uses

4-(3-Pyridinyl)-2-pyrimidinamine serves as an intermediate compound during the synthesis of Nilotinib. Nilotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of chronic myelogenous leukemia.

Synthesis

3-(Dimethylamino)-1-(pyridine-3-yl) prop-2-en-1-one (15.4 g, 0.088 mol), guanidine nitrate (10.7 g, 0.088 mol), and sodium hydroxide (3.5 g, 0.088 mol) were dissolved in n-butanol (120 mL). The mixture was heated to reflux with stirring and maintained for 16 hours. The reaction mixture was then cooled to room temperature. The solid was collected and washed with water (400 mL). The desired product was dried under vacuum for three days, and 12.7 g of yellow crystals of 4-(Pyridin-3-yl)pyrimidin-2-amine was obtained (yield: 85 %).

4-(Pyridin-3-yl)pyrimidin-2-amine Preparation Products And Raw materials

Raw materials

Ethanol N,N-Dimethylformamide Sodium N,N-Dimethylformamide dimethyl acetal 3-Acetylpyridine

Preparation Products

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester Imatinib

4-(Pyridin-3-yl)pyrimidin-2-amine Suppliers

Global( 177)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
ALS INDIA LIFE SCIENCES	+91-8977036379 +91-8977036379	Hyderabad, India	1879	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pratap Organics Private Limited	08048361325Ext 960	Mumbai, India	32	58	Inquiry
Hongxiong	+undefined18915499068	China	120	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29901	58	Inquiry

Supplier	Advantage
ALS INDIA LIFE SCIENCES	58
TCI Chemicals (India) Pvt. Ltd.	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pratap Organics Private Limited	58
Hongxiong	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58

66521-66-2(4-(Pyridin-3-yl)pyrimidin-2-amine)Related Search:

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Nilotinib N-Oxide Nilotinib Impurity 4 Benzenamine, 3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)- Nilotinib 3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine

3-Iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide 3-(2,4-dimethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-Benzenamine N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine Imatinib

N-Desmethyl Imatinib 2-METHYL-N1-[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-1,4-BENZENEDIAMINE 4-METHYL-6-PYRIDIN-3-YLPYRIMIDIN-2-AMINE

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BUTTPARK 41\09-83 4-(3-PYRIDINYL)-2-PYRIMIDINAMINE 4-(3-PYRIDINYL)-2-PYRIMIDINE AMINE 4-(3-PYRIDINYL)-2-PYRIMIDINYLAMINE 4-(3-Pyridyl)-2-pyrimidinamine 4-(3-Pyridinyl)-2-aminopyrimidine 4-(3-Pyridyl)-2-pyrimidineamine 4-(3-Pyridinyl)-2-pyrimidine amine ,97% 2-amino-4-(3-pyridinyl)-pyrimidine 4-Pyridin-3-yl-pyriMidin-2-ylaMine 2-PyriMidinaMine,4-(3-pyridinyl)- 2-Amino-4-(3-pyridyl)pyrimidine 4-(3-piridinyl)-2-pirimidine amine 4-(3-Pyridinyl)-2-pyrimidine amine, 97%, reagent grade )-2-pyrimidine amine Nilotinib 3-Pyridinyl Impurity 4-(3-Pyridinyl)-2-aminopyrimidine ISO 9001：2015 REACH 4-(3-Pyridinyl)-2-aminopyrimidineQ: What is 4-(3-Pyridinyl)-2-aminopyrimidine Q: What is the CAS Number of 4-(3-Pyridinyl)-2-aminopyrimidine Q: What is the storage condition of 4-(3-Pyridinyl)-2-aminopyrimidine Q: What are the applications of 4-(3-Pyridinyl)-2-aminopyrimidine 4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE 66521-66-2 C9H8N4 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals