PENITREM A

PENITREM A Structure
CAS No.
12627-35-9
Chemical Name:
PENITREM A
Synonyms
PENITREM A;TREMORTIN A;JDUWHZOLEDOQSR-JKPSMKLGSA-N;Penitrem A Nsc354845;PENITREM A, PENICILLIUM PAXILLI;Penitrem A from Penicillium paxilli;penitrem A from penicillium palitans;7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol, 12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-, (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14b...;2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
CBNumber:
CB4155421
Molecular Formula:
C37H44ClNO6
Molecular Weight:
634.2
MOL File:
12627-35-9.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59

PENITREM A Properties

Melting point 238°C
Density 1.0241 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 6 mg/ml)
form White solid.
pka 13.22±0.70(Predicted)
color Amorphous solid
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P301+P330+P331+P310
Hazard Codes  T+,T
Risk Statements  26/27/28
Safety Statements  36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  RY7535000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29349990
Toxicity LD50 orl-mus: 10 mg/kg 41KEAL -,108,78
NFPA 704
0
4 0

PENITREM A price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) P3053 Penitrem A ≥95% (HPLC and TLC) 12627-35-9 1MG ₹30223.4 2022-06-14 Buy
Sigma-Aldrich(India) P3053 Penitrem A ≥95% (HPLC and TLC) 12627-35-9 5MG ₹101257.05 2022-06-14 Buy
Product number Packaging Price Buy
P3053 1MG ₹30223.4 Buy
P3053 5MG ₹101257.05 Buy

PENITREM A Chemical Properties,Uses,Production

Chemical Properties

Solid

Occurrence

A series of closely related metabolites of Penicillium crustosum has recently been isolated and the components separated chromatographically. Penitrem A forms colourless crystals from EtOH.

Uses

Penitrem A is a tremorgenic mycotoxin isolated from Penicillium species. Penitrem A is a selective blocker of high-conductance Ca2+-activated potassium channels.

Safety Profile

Poison by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Clí and NOx.

PENITREM A Preparation Products And Raw materials

Raw materials

Preparation Products

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TREMORTIN A Penitrem A from Penicillium paxilli PENITREM A PENITREM A, PENICILLIUM PAXILLI penitrem A from penicillium palitans Penitrem A Nsc354845 JDUWHZOLEDOQSR-JKPSMKLGSA-N 2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol 7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol, 12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-, (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14b... 12627-35-9 C37H44ClNO6 BioChemical Cell Signaling and Neuroscience Cell Biology Monovalent Ion Channels Potassium Channel Modulators Ion Channels Voltage-gated Ion Channels antibiotic