CARBINOXAMINE MALEATE SALT
- CAS No.
- 3505-38-2
- Chemical Name:
- CARBINOXAMINE MALEATE SALT
- Synonyms
- clistin;ciberon;lergefin;hislosine; Allergefon;Maleate clistinmaleate;clistinemaleate;allergefonmaleate;CarbinoxaMine
- CBNumber:
- CB4183800
- Molecular Formula:
- C20H23ClN2O5
- Molecular Weight:
- 406.86
- MOL File:
- 3505-38-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/10 17:45:06
| Melting point | 116-1180C |
|---|---|
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| Water Solubility | Completely soluble in water |
| solubility | Chloroform: Slightly Soluble; Methanol: Slightly Soluble |
| form | Solid |
| color | White to Almost white |
| Merck | 14,1799 |
| InChIKey | GVNWHCVWDRNXAZ-BTJKTKAUSA-N |
| CAS DataBase Reference | 3505-38-2(CAS DataBase Reference) |
| EPA Substance Registry System | Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) (3505-38-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US6350000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933399090 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 166 i.p. (Cahen) | |||||||||
| NFPA 704 |
|
CARBINOXAMINE MALEATE SALT price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2802 | Carbinoxamine Maleate certified reference material, pharmaceutical secondary standard | 3505-38-2 | 400MG | ₹22342.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C8278 | Carbinoxamine maleate salt analytical standard | 3505-38-2 | 10G | ₹15717.9 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C3057 | Carbinoxamine Maleate | 3505-38-2 | 5G | ₹3900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C3057 | Carbinoxamine Maleate | 3505-38-2 | 25G | ₹8000 | 2022-05-26 | Buy |
CARBINOXAMINE MALEATE SALT Chemical Properties,Uses,Production
Description
Carbinoxamine is a competitive histamine H1 receptor antagonist (Ki = 2.3 nM) and first generation antihistamine. It also competes with [3H]diltiazem, an L-type calcium channel blocker, for binding to the benzothiazepine site on rat cardiomyocytes (Ki = 1.08 nM). Carbinoxamine decreases negative inotropic activity in isolated guinea pig left atria by 76% (EC50 = 250 nM) and negative chronotropic activity in guinea pig spontaneously beating isolated right atria (EC50s = 250 and 480 nM, respectively) by 48% compared with control. Formulations containing carbinoxamine have been used in the treatment of allergic rhinitis.
Chemical Properties
Off-White Solid
Uses
Analgesic and anti-inflammatory compound
Definition
ChEBI: The maleic acid salt of carbinoxamine. An ethanolamine-type antihistamine, used for treating hay fever, as well as mild cases of Parkinson's disease.
General Description
Carbinoxamine is availableas a bitter bimaleate salt, (d, l)-2-[p-chloro- -[2-(dimethylamino)ethoxy]benzyl]pyridine bimaleate (Clistin), which isa white crystalline powder that is very soluble in water andfreely soluble in alcohol and in chloroform. The pH of a 1%solution is between 4.6 and 5.1.
Carbinoxamine is a potent antihistaminic and is availableas the racemic mixture. It differs structurally from chlorpheniramineonly in having an oxygen atom separate theasymmetric carbon atom from the aminoethyl side chain. Themore active levo isomer of carbinoxamine has the (S) absoluteconfiguration and can be superimposed on the moreactive dextro isomer (S configuration) of chlorpheniramine.
CARBINOXAMINE MALEATE SALT Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| R L Fine Chem Pvt. Ltd | +91-8042488999 +91-8042488999 | Karnataka, India | 74 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| RL FINE CHEM PVT LTD | +91-8042488999 | New Delhi, India | 49 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Jai Radhe Sales | 0091-79-26431096 | New Delhi, India | 157 | 57 | Inquiry |
| METROCHEM API PRIVATE LTD | +91 - 40 -2370 0421 | Hyderabad, India | 41 | 58 | Inquiry |
| M S Pharmachem | 91-22-32910305 | Maharashtra, India | 56 | 58 | Inquiry |
| MSN Laboratories Pvt., Ltd. | 91-40-30438600 | Hyderabad, India | 38 | 58 | Inquiry |
| Resonance Laboratories Private Limited | 08066085747Ext 283 | Karnataka, India | 13 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| R L Fine Chem Pvt. Ltd | 58 |
| Hetero Drugs Limited | 58 |
| Ralington Pharma | 58 |
| RL FINE CHEM PVT LTD | 58 |
| Clearsynth Labs | 58 |
| Jai Radhe Sales | 57 |
| METROCHEM API PRIVATE LTD | 58 |
| M S Pharmachem | 58 |
| MSN Laboratories Pvt., Ltd. | 58 |
| Resonance Laboratories Private Limited | 58 |
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