1,4,7-Triazacyclononane
- CAS No.
- 4730-54-5
- Chemical Name:
- 1,4,7-Triazacyclononane
- Synonyms
- TACN;157715;1,4,7-triazonane;Triazacyclononane;TRIETHYLENETRIAMINE;1,4,8-Triazacyclononane;1,4,7-Triazacyclonomane;1,4,7-TRIAZACYCLONONANE;Triazacyclononanewhitextl;1,4,7-Triazacyclononane hcl
- CBNumber:
- CB4234922
- Molecular Formula:
- C6H15N3
- Molecular Weight:
- 129.2
- MOL File:
- 4730-54-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/12 15:55:19
| Melting point | 42-45 °C (lit.) |
|---|---|
| Boiling point | 110-130 °C/7 mmHg (lit.) |
| Density | 0.9987 (rough estimate) |
| refractive index | 1.4620 (estimate) |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| Water Solubility | Soluble in water |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 10.57±0.20(Predicted) |
| form | crystal |
| color | white |
| BRN | 773877 |
| InChIKey | ITWBWJFEJCHKSN-UHFFFAOYSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3259 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10-34 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
1,4,7-Triazacyclononane price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 311308 | 1,4,7-Triazacyclononane 95% | 4730-54-5 | 100MG | ₹5206.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 311308 | 1,4,7-Triazacyclononane 95% | 4730-54-5 | 500MG | ₹19041.18 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T1878 | 1,4,7-Triazacyclononane min. 98.0 % | 4730-54-5 | 200MG | ₹9800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T1878 | 1,4,7-Triazacyclononane min. 98.0 % | 4730-54-5 | 1G | ₹16500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T1878 | 1,4,7-Triazacyclononane min. 98.0 % | 4730-54-5 | 5G | ₹56400 | 2022-05-26 | Buy |
1,4,7-Triazacyclononane Chemical Properties,Uses,Production
Description
1,4,7-Triazacyclononane, known as "TACN" which is pronounced "tack-en," is a cyclic organic compound with the formula C6H12(NH)3. TACN is derived, formally speaking, from cyclononane by replacing three equidistant CH2 groups with NH groups. TACN is one of the oligomers derived from aziridine, C2H4NH. Other members of the series include diazacyclohexane, C4H8(NH)2, and the cyclic tetramer 1,4,7,10-tetraazacyclododecane.
Chemical Properties
White - light yellow solid
Uses
1,4,7-Triazacyclononane (TACN) is a versatile platform from which various ligands can be derived to form effective chelators for (radio)copper(II) complexation. The ability of TACN-derivatives to form highly stable complexes with copper(II) is greatly influenced by the number and type of substituents on the macrocyclic ring. The formed copper(II) complexes show a broad variability in their thermodynamic stability and kinetic inertness, varying in structure from square-pyramidal to distorted octahedral. TACN-based BFCAs have also been used for indirect radiolabelling of biomolecules, rendering them suitable for imaging and therapy.
Preparation
The ligand is prepared from diethylene triamine as follows by macrocyclization using ethyleneglycol ditosylate.
H2NCH2CH2NHCH2CH2NH2 + 3 TsCl → Ts(H)NCH2CH2N(Ts)CH2CHH2N(H)Ts + 3 HCl Ts(H)NCH2CH2N(Ts)CH2CH2N(H)Ts + 2 NaOEt → Ts(Na)NCH2CH2N(Ts)CH2CH2N(Na)Ts Ts(Na)NCHH2CH2N(Ts)CH2CH2N(Na)Ts + TsOCH2CH2OTs + → [(CH2CH2N(Ts)]3 + 2 NaOTs [(CH2CH2N(Ts)]3 + 3 H2O → [CH2CH2NH]3 + 3 HOTs
Application
Starting material for the synthesis of 1,4,7-trifunctionalized derivatives which have applications in metal complexation.
Possible reagent for compleximetric titrations with high cation-binding selectivity.
1,4,7-Triazacyclononane Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Chemi Care | 08048250474Ext 463 | Mumbai, India | 51 | 58 | Inquiry |
| Pon Pure Chem (P) Ltd. | 91-44-26161803 | Tamil Nadu, India | 58 | 58 | Inquiry |
| Antares Chem Private Limited | 08048957399 | Mumbai, India | 181 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | China | 2999 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29889 | 58 | Inquiry |
| Accela ChemBio Inc. | +1-858-6993322 | United States | 19447 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CHEMSWORTH | 30 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Chemi Care | 58 |
| Pon Pure Chem (P) Ltd. | 58 |
| Antares Chem Private Limited | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 58 |
| Capot Chemical Co.,Ltd. | 60 |
| career henan chemical co | 58 |
| Accela ChemBio Inc. | 58 |
| Chongqing Chemdad Co., Ltd | 58 |
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