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PD 166866

PD 166866 Structure
CAS No.
192705-79-6
Chemical Name:
PD 166866
Synonyms
CS-2496;PD 166866;PD-166866;PD 166866;FGF Receptor Tyrosine Kinase Inhibitor;FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem;tert-butyl (2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)carbamate;1-(2-aMino-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl)-3-(tert-butyl)urea;N-[2-AMino-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl]-N'-(1,1-diMethylethyl);Inhibitor,Autophagy,FGFR,inhibit,PD-166866,PD 166866,Fibroblast growth factor receptor;Urea, N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-
CBNumber:
CB42485694
Molecular Formula:
C20H24N6O3
Molecular Weight:
396.44
MOL File:
192705-79-6.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:02:51
Request For Quotation

PD 166866 Properties

Melting point 291-293°C
storage temp. 2-8°C
solubility DMSO: ≥10mg/mL
form Off-white solid
color off-white to light tan

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  Xn
Risk Statements  22
WGK Germany  1
NFPA 704
0
2 0

PD 166866 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0114 PD-166866 ≥98% (HPLC) 192705-79-6 5MG ₹13206.5 2022-06-14 Buy
Sigma-Aldrich(India) PZ0114 PD-166866 ≥98% (HPLC) 192705-79-6 25MG ₹51180.6 2022-06-14 Buy
Sigma-Aldrich(India) 341608 FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem The FGF Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 192705-79-6, controls the biological activity of FGF Receptor Tyrosine Kinase. T 192705-79-6 5MG ₹19050 2022-06-14 Buy
Product number Packaging Price Buy
PZ0114 5MG ₹13206.5 Buy
PZ0114 25MG ₹51180.6 Buy
341608 5MG ₹19050 Buy

PD 166866 Chemical Properties,Uses,Production

Description

PD 166866 is a potent inhibitor of fibroblast growth factor receptor 1 (FGFR1; IC50 = 52.4 nM; Ki = 45.2 nM). It is selective for FGFR1 over PDGFR, EGFR, C-SRC, MEK, PKC, insulin receptor tyrosine kinase, and CDK4 (IC50s = >50 μM). PD 166866 inhibits FGFR1 autophosphorylation in NIH3T3 and L6 cells (IC50s = 10.8 and 3.1 nM, respectively) and inhibits phosphorylation of MAPK (IC50s = 4.3 and 7.9 nM for the 44- and 42-kDa MAPK isoforms, respectively). It reduces FGF- but not EGF- or PDGF-stimulated growth of L6 cells and inhibits microvessel outgrowth from human placental arteries in vitro. PD 166866 inhibits the growth of non-small cell lung cancer (NSCLC) cell lines in a dose-dependent manner and reduces migration of VL-8 cells at a concentration of 10 μM.

Chemical Properties

Off-White Solid

Uses

A novel potent ATP competitive pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. An inhibitor of the basic fibroplast growth factor (bFGF).

PD 166866 Preparation Products And Raw materials

Raw materials

Preparation Products

PD 166866 Suppliers

Global( 75)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 China 42057 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Jilin Chinese Academy of Sciences-yanshen Technology 58

192705-79-6(PD 166866)Related Search:

PD 173074 PD 166285 PD 0325901 PD 123319 ditrifluoroacetate 4-(4-FLUOROPHENYL)-2-(4-NITROPHENYL)-5-(4-PYRIDYL)-1H-IMIDAZOLE
PD153035 HCl N-[2-[[4-(DIETHYLAMINO)BUTYL]AMINO-6-(3,5-DIMETHOXYPHENYL)PYRIDO[2,3-D]PYRIMIDIN-7-YL]-N'-(1,1-DIMETHYLETHYL)UREA PD 158780 PD168393
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PD 166866 N-[2-AMino-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl]-N'-(1,1-diMethylethyl) 1-(2-aMino-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl)-3-(tert-butyl)urea tert-butyl (2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)carbamate FGF Receptor Tyrosine Kinase Inhibitor CS-2496 FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem PD-166866;PD 166866 Urea, N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)- Inhibitor,Autophagy,FGFR,inhibit,PD-166866,PD 166866,Fibroblast growth factor receptor 192705-79-6 API Amines Aromatics Bases & Related Reagents Heterocycles Intermediates & Fine Chemicals Nucleotides Pharmaceuticals