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ROTTLERIN

ROTTLERIN Structure
CAS No.
82-08-6
Chemical Name:
ROTTLERIN
Synonyms
MALLOTOXIN;kamalin;NSC 94525;NSC 56346;ROTTLERIN;Rottierin;Rottlerin,98%;Rottlerin, 98% 10MG;Rottlerin (Mallotoxin;4’,6’-trihydroxy-5’-methyl-methyl)-2
CBNumber:
CB4260488
Molecular Formula:
C30H28O8
Molecular Weight:
516.54
MOL File:
82-08-6.mol
Modify Date:
2023/6/30 15:45:59
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ROTTLERIN Properties

Melting point 200 °C
Boiling point 521.39°C (rough estimate)
Density 1.2051 (rough estimate)
refractive index 1.4900 (estimate)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 50 mg/ml).
form Powder
pka 6.92±0.40(Predicted)
color Orange to brown
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
LogP 8.660 (est)
CAS DataBase Reference 82-08-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Hazard Codes  Xn
Risk Statements  20/21/22-22
Safety Statements  36/37-24/25
WGK Germany  3
RTECS  AM6913800
HS Code  29329990

ROTTLERIN price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 557370 Rottlerin - CAS 82-08-6 - Calbiochem A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC?? = 3-6 μM) and PKCθ. 82-08-6 10MG ₹14260 2022-06-14 Buy
Product number Packaging Price Buy
557370 10MG ₹14260 Buy

ROTTLERIN Chemical Properties,Uses,Production

Chemical Properties

orange to brown powder

Uses

Rottlerin is a human ether-a-go-go-related gene (hERG) potassium channel activator.

Definition

ChEBI: A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.

General Description

Rottlerin is extracted from Mallotus philippinensis. It is a protein kinase Cδ (PKCδ) inhibitor. Rottlerin acts as an uncoupler of mitochondrial respiration from oxidative phosphorylation. It has antitumor, autophagy, anti-proliferative, anti-metastasis and anti-invasive properties.

Biological Activity

Originally reported to inhibit PKC isoforms, with selectivity for PKC δ (K i values are 30, 42, 40, 3-6, 100, and 100 μ M for α , β , γ , δ , ε , λ respectively). Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC 50 values are 1.9 and 5 μ M respectively). Also shown to act as a direct mitochondrial uncoupler.

ROTTLERIN Preparation Products And Raw materials

Raw materials

Preparation Products

ROTTLERIN Suppliers

Global( 134)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Shaanxi LonierHerb Bio Technology Co Ltd +86-86-+86-86-029-87551862 +8617702909819 China 2605 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
ABCR GmbH & CO. KG 49 721 95061 0 Germany 6846 75 Inquiry
LC Laboratories +1 (781) 937-0777 United States 503 50 Inquiry
Aikon International Limited 025-58851090 13611564524 China 15952 58 Inquiry
amyjetsci 027-59626688 18771149750 China 3004 58 Inquiry
Supplier Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd 58
CLEARSYNTH LABS LTD. 58
TargetMol Chemicals Inc. 58
InvivoChem 58
Shaanxi LonierHerb Bio Technology Co Ltd 58
Aladdin Scientific 58
ABCR GmbH & CO. KG 75
LC Laboratories 50
Aikon International Limited 58
amyjetsci 58

82-08-6(ROTTLERIN)Related Search:

3-Ethylacetophenone 3,5-Dimethyl-4-hydroxybenzaldehyde 3-VINYLBENZALDEHYDE 1-(2-Hydroxy-5-methylphenyl)ethanone 2',4'-DIHYDROXY-3'-METHYLACETOPHENONE
2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE ROTTLERIN 2,4-Dihydroxy-3-methylbenzaldehyde ALLYL P-TOLYL ETHER 3,5-DIMETHYLACETOPHENONE
2,2'-METHYLENEBIS(4-METHYLPHENOL) 2,4,6-Trimethylphenol 2,2'-METHYLENEDIPHENOL 2-ALLYLOXYBENZALDEHYDE 5-ETHYL-2-HYDROXY-BENZALDEHYDE
1-(2-ETHOXY-5-METHYL-PHENYL)-ETHANONE 2,4-DIHYDROXY-1,3,5-TRIMETHYLBENZENE 2-BENZYL-4-METHYLPHENOL
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3'-[(8-CINNAMOYL-5,7-DIHYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-6-YL)METHYL]-2',4',6'-TRIHYDROXY-5'-METHYLACETOPHENONE 4’,6’-trihydroxy-5’-methyl-methyl)-2 acetophenone,3’-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-6-yl) 2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (2E)- 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one (E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one Rottlerin,98% Rottlerin, 98% 10MG ROTTLERIN NSC 56346 NSC 94525 Rottlerin (Mallotoxin MALLOTOXIN kamalin (E)-1-(6-(3-Acetyl-2,4,6-trihydroxy-5-methylbenzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl)-3-phenylprop-2-en-1-one Rottierin 82-08-6 1982-8-6 C30H28O8 Kinase/Phosphatase Biology Protein Kinase C, Calcium/Calmodulin-dependent protein Kinase (PKC and CaMK) Serine/Threonine Kinase Inhibitors Cell Signaling and Neuroscience Cell Biology BioChemical Aromatic Phenols Protein Kinase