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ChemicalBook > Product Catalogue >Biochemical Engineering >Plant extracts >ROTTLERIN

ROTTLERIN

ROTTLERIN Structure
  • ₹14260
  • Product name: ROTTLERIN
  • CAS: 82-08-6
  • MF: C30H28O8
  • MW: 516.54
  • EINECS:201-395-4
  • MDL Number:MFCD00017361
  • Synonyms:3'-[(8-CINNAMOYL-5,7-DIHYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-6-YL)METHYL]-2',4',6'-TRIHYDROXY-5'-METHYLACETOPHENONE;4’,6’-trihydroxy-5’-methyl-methyl)-2 ;acetophenone,3’-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-6-yl) ;2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (2E)-;1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one;(E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one;Rottlerin,98%;Rottlerin, 98% 10MG
Price1 Properties Safety Information Description
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Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • ManufacturerSigma-Aldrich(India)
  • Product number557370
  • Product descriptionRottlerin - CAS 82-08-6 - Calbiochem A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC?? = 3-6 μM) and PKCθ.
  • Packaging10MG
  • Price₹14260
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 557370 Rottlerin - CAS 82-08-6 - Calbiochem A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC?? = 3-6 μM) and PKCθ. 10MG ₹14260 2022-06-14 Buy

Properties

Melting point :200 °C
Boiling point :521.39°C (rough estimate)
Density :1.2051 (rough estimate)
refractive index :1.4900 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml).
form :Powder
pka :6.92±0.40(Predicted)
color :Orange to brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
LogP :8.660 (est)
CAS DataBase Reference :82-08-6(CAS DataBase Reference)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Rottlerin was originally identified as an inhibitor of PKCδ (IC50 = 3 μM), but can also inhibit CAM kinase III and a wide range of protein kinases, including PRAK and MAPKAP-K2 (IC50s = 1.9 and 5 μM, respectively). It can act as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin has also been shown to have neuroprotective effects in an MPTP animal model of Parkinson’s disease.

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