ROTTLERIN
- ₹14260
- Product name: ROTTLERIN
- CAS: 82-08-6
- MF: C30H28O8
- MW: 516.54
- EINECS:201-395-4
- MDL Number:MFCD00017361
- Synonyms:3'-[(8-CINNAMOYL-5,7-DIHYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-6-YL)METHYL]-2',4',6'-TRIHYDROXY-5'-METHYLACETOPHENONE;4’,6’-trihydroxy-5’-methyl-methyl)-2 ;acetophenone,3’-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-6-yl) ;2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (2E)-;1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one;(E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one;Rottlerin,98%;Rottlerin, 98% 10MG
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Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number557370
- Product descriptionRottlerin - CAS 82-08-6 - Calbiochem A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC?? = 3-6 μM) and PKCθ.
- Packaging10MG
- Price₹14260
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 557370 | Rottlerin - CAS 82-08-6 - Calbiochem A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC?? = 3-6 μM) and PKCθ. | 10MG | ₹14260 | 2022-06-14 | Buy |
Properties
Melting point :200 °C
Boiling point :521.39°C (rough estimate)
Density :1.2051 (rough estimate)
refractive index :1.4900 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml).
form :Powder
pka :6.92±0.40(Predicted)
color :Orange to brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
LogP :8.660 (est)
CAS DataBase Reference :82-08-6(CAS DataBase Reference)
Boiling point :521.39°C (rough estimate)
Density :1.2051 (rough estimate)
refractive index :1.4900 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml).
form :Powder
pka :6.92±0.40(Predicted)
color :Orange to brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
LogP :8.660 (est)
CAS DataBase Reference :82-08-6(CAS DataBase Reference)
Safety Information
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Description
Rottlerin was originally identified as an inhibitor of PKCδ (IC50 = 3 μM), but can also inhibit CAM kinase III and a wide range of protein kinases, including PRAK and MAPKAP-K2 (IC50s = 1.9 and 5 μM, respectively). It can act as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin has also been shown to have neuroprotective effects in an MPTP animal model of Parkinson’s disease.More related product prices
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