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BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Structure
CAS No.
1054543-47-3
Chemical Name:
BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-
Synonyms
Apoptozole;CS-2225;Apoptozole（AZ）;APOPTOSIS ACTIVATOR VII;5-bis(trifluoroMethyl)phenyl]-4;Apoptozole，Apoptosis Activator VII;Apoptosis Activator VII, Apoptozole;6-BROMO-4-CHLOROQUINOLINE HYDROCHLORIDE (1:1);5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-;Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem
CBNumber:
CB42627395
Molecular Formula:
C33H25F6N3O3
Molecular Weight:
625.56
MOL File:
1054543-47-3.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:07
Request For Quotation

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Properties

Melting point 225-228°C
Boiling point 703.5±70.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. +2C to +8C
solubility DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form White solid
pka 15.98±0.50(Predicted)
color White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Chemical Properties,Uses,Production

General Description

A cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 h drug treatment (1 μM). Shown to suppress ubiquitination of mutant CFTR and promote membrane trafficking, and restore chloride channel activity.

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Suppliers

Global( 68)Suppliers
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A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. +8618068519287 China 833 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
Career Henan Chemica Co 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
LEAPCHEM CO., LTD. 58

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Spectrum

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-(1054543-47-3)1HNMR

1054543-47-3(BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-)Related Search:

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BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Apoptosis Activator VII, Apoptozole 6-BROMO-4-CHLOROQUINOLINE HYDROCHLORIDE (1:1) 5-bis(trifluoroMethyl)phenyl]-4 5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem 4-({2-[3,5-Bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1 H-imidazol-1-yl}methyl)benzamide Apoptozole，Apoptosis Activator VII 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzamide APOPTOSIS ACTIVATOR VII CS-2225 Apoptozole domain,Heat shock proteins,inhibit,Inhibitor,Apoptosis,HSP,Hsp70,Apoptozole,ATPase,Hsc70 Apoptozole（AZ） 1054543-47-3 C33H25F6N3O3