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CCT 244747

CCT 244747 Structure
CAS No.
1404095-34-6
Chemical Name:
CCT 244747
Synonyms
CS-1625;CCT 244747;CCT-244747; CCT 244747;CCT244747; CCT-244747; CCT 244747;3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile;3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile;2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-
CBNumber:
CB92668551
Molecular Formula:
C20H24N8O2
Molecular Weight:
408.46
MOL File:
1404095-34-6.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:41
Request For Quotation

CCT 244747 Properties

Boiling point 562.6±50.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form A solid
pka 8.15±0.28(Predicted)
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P264-P270-P280-P301+P312-P330-P305+P351+P338-P310-P501
NFPA 704
0
3 0

CCT 244747 Chemical Properties,Uses,Production

Description

CCT244747 is a potent inhibitor of checkpoint kinase 1 (Chk1; IC50 = 8 nM). It is selective for Chk1 over FLT3, Chk2, and CDK1 (IC50s = 600, >10,000, and >10,000 nM, respectively) as well as a panel of 121 additional kinases at a concentration of 10 μM. CCT244747 reverses cell cycle arrest at the G2/M phase induced by etoposide and SN-38 in HT-29 cells and gemcitabine (Item Nos. 11690 | 9003096) in SW620 cells, indicating cellular G2 checkpoint abrogation. It potentiates the genotoxicity of SN-38, gemcitabine, and etoposide in HT-29, SW620, MiaPaCa-2, and Calu-6 cells with potentiation index (PI) values ranging from 1.9-8.5, 2.6-12.2, 5-16, and 1.4-5.6, respectively. In vivo, CCT244747 (75 mg/kg), in combination with irinotecan or gemcitabine, increases the delay of tumor growth in SW620 and Calu-6 mouse xenograft models, respectively.

CCT 244747 Preparation Products And Raw materials

Raw materials

Preparation Products

CCT 244747 Suppliers

Global( 61)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9274 58 Inquiry
TargetMol Chemicals Inc. 15002134094 China 28091 58 Inquiry
InvivoChem 13549236410 China 6747 58 Inquiry
DC Chemicals 021-58447131 13564518121 China 9412 58 Inquiry
HangZhou YuHao Chemical Technology Co., Ltd. 0571-82693216 China 2031 58 Inquiry
Beijing Lebo Biotechnology Co., Ltd. 010-50934026 CHINA 6057 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
InvivoChem 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58
InvivoChem 58
DC Chemicals 58
HangZhou YuHao Chemical Technology Co., Ltd. 58
Beijing Lebo Biotechnology Co., Ltd. 58

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CCT 244747 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile 3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile CCT244747; CCT-244747; CCT 244747 CS-1625 CCT-244747; CCT 244747 2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]- 1404095-34-6 C20H24N8O2