Sulfacetamide
- CAS No.
- 144-80-9
- Chemical Name:
- Sulfacetamide
- Synonyms
- A-500;Region;Oclucid;Sebizon;Albucid;Alesten;Sulamyd;Sulf-10;sultrin;Acetocid
- CBNumber:
- CB4264350
- Molecular Formula:
- C8H10N2O3S
- Molecular Weight:
- 214.24
- MOL File:
- 144-80-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/2 22:45:52
| Melting point | 182-184 °C |
|---|---|
| Density | 1.3844 (rough estimate) |
| refractive index | 1.5690 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | ethanol: soluble50mg/mL |
| pka | pKa 1.76±0.04(H2O t = 25 I = 0.15 (KCl) Ar atmosphere)(Approximate);5.22±0.01(H2O t = 25 I = 0.15 (KCl) Ar atmosphere)(Approximate) |
| form | powder |
| color | white to off-white |
| Water Solubility | <0.01 g/100 mL at 16 ºC |
| Merck | 14,8899 |
| BRN | 981718 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, strong acids. |
| InChIKey | SKIVFJLNDNKQPD-UHFFFAOYSA-N |
| CAS DataBase Reference | 144-80-9(CAS DataBase Reference) |
| NIST Chemistry Reference | N-(p-Aminobenzenesulfonyl)acetamide(144-80-9) |
| EPA Substance Registry System | Sulfacetamide (144-80-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H335 | |||||||||
| Precautionary statements | P261-P271-P272-P280-P302+P352-P304+P340+P312 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36-26 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AC8450000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29350090 | |||||||||
| Toxicity | LD50 orally in dogs: 8000 mg/kg (Fisher) | |||||||||
| NFPA 704 |
|
Sulfacetamide price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S8627 | Sulfacetamide ≥98.0% | 144-80-9 | 500G | ₹12751.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1498 | Sulfacetamide Pharmaceutical Secondary Standard; Certified Reference Material | 144-80-9 | 1G | ₹12145.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 46770 | Sulfacetamide VETRANAL?, analytical standard | 144-80-9 | 250MG | ₹4351.65 | 2022-06-14 | Buy |
| TCI Chemicals (India) | S0577 | Sulfacetamide | 144-80-9 | 25G | ₹2400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | S0577 | Sulfacetamide | 144-80-9 | 250G | ₹9700 | 2022-05-26 | Buy |
Sulfacetamide Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Definition
ChEBI: A sulfonamide that is sulfanilamide acylated on the sulfonamide nitrogen.
General Description
Sulfacetamide’s plasmahalf-life is 7 hours. This compound is a white crystallinepowder, soluble in water (1:62.5 at 37°C) and in alcohol. It is very soluble in hot water, and its water solution is acidic.It has a pKa of 5.4.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
N-((4-Aminophenyl)sulfonyl)acetamide is an amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generate mixed oxides of nitrogen (NOx)
Fire Hazard
Flash point data for N-((4-Aminophenyl)sulfonyl)acetamide are not available. N-((4-Aminophenyl)sulfonyl)acetamide is probably combustible.
Pharmaceutical Applications
N-acetylsulfanilamide. It is very soluble in water and was
formerly used in urinary tract infection. It is available in
some countries in ophthalmic preparations and as a component
(with sulfathiazole and sulfabenzamide) of a triple
sulfonamide cream for the topical treatment of bacterial
vaginosis.
Sulfacetamide is one of the least active sulfonamides. It
is well absorbed when given orally and is excreted in the
urine with a half-life of around 9 h. About 70% is excreted
unchanged, the remainder being present as the acetyl metabolite.
Adverse reactions are those common to the group.
Stevens–Johnson syndrome has been reported several times
after topical use in conjunctivitis.
Safety Profile
Mildly toxic by ingestion and intravenous routes. An experimental teratogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Purification Methods
Crystallise the amide from aqueous EtOH. [Beilstein 14 IV 2662.]
Sulfacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ishita Drugs And Industries Ltd | +91-7226995614 +91-7226995613 | Telangana, India | 47 | 58 | Inquiry |
| Innovative Synthetic Molecules | +91 40-24111684 | Hyderabad, India | 527 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Artichempharma (Aarti Dye Chem) | 91-9687052936 | Gujarat, India | 37 | 58 | Inquiry |
| Ishita Drugs & Industries Ltd. | 09228016102 | Ahmedabad, India | 33 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |