A23187
- CAS No.
- 52665-69-7
- Chemical Name:
- A23187
- Synonyms
- SBE-β-CD;CALCIMYCIN;A23187, 98%, FREE ACID;CALCIUM IONOPHORE A23187;5-(Methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid;11B1;A23187;(R*),9B2;Calimycin;(2S*,3S*),8B2
- CBNumber:
- CB4315720
- Molecular Formula:
- C29H37N3O6
- Molecular Weight:
- 523.62
- MOL File:
- 52665-69-7.mol
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 187-190 °C |
|---|---|
| alpha | D25 -56° (c = 1 in chloroform) |
| Boiling point | 710.3±55.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO with warming or sonication. Also soluble in ethanol or ethyl acetate |
| form | Solid |
| pka | pKa1 6.9 in 90% DMSO |
| color | white to light yellow |
| Merck | 13,1639 |
| BRN | 1096801 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 4 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DM4676000 | |||||||||
| F | 8 | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 i.p. in mice: 10 mg/kg (Gale) | |||||||||
| NFPA 704 |
|
A23187 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C7522 | Calcium Ionophore A23187 ≥98% (TLC), powder | 52665-69-7 | 1MG | ₹6408.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C7522 | Calcium Ionophore A23187 ≥98% (TLC), powder | 52665-69-7 | 5MG | ₹15165.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C7522 | Calcium Ionophore A23187 ≥98% (TLC), powder | 52665-69-7 | 10MG | ₹24085.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C7522 | Calcium Ionophore A23187 ≥98% (TLC), powder | 52665-69-7 | 50MG | ₹88570.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 100105 | A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem A mobile ion-carrier that forms stable complexes with divalent cations. | 52665-69-7 | 1MG | ₹4630.01 | 2022-06-14 | Buy |
A23187 Chemical Properties,Uses,Production
Chemical Properties
white to off-white solid
Uses
A23187 (Mixed Calcium-Magnesium Salt) is used in cell activation experiments when calcium dose-response data are not required. Ca-Mg ratio ~ 1:1. it is widely used as a compound in cell activation. It is used as a highly selective Ca2+ ionophore. it is used in studies of intracellular Ca2+ mediated events. A23187 has been observed to induce cell activation, differentiation or proliferation. In vitro experimentation has shown A23187 to boost ROS generation and platelet fragmentation. A23187 is a widely used ionophore. It has the ability to increase the intracellular concentrations of cations and is widely used to increase the intracellular levels of calcium. Visualization of Synaptic Ca2+ Calmodulin-Dependent Protein Kinase II Activity in Living Neurons.
General Description
A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
Biological Activity
Calcium ionophore that induces Ca 2+ -dependent cell death by increasing intracellular calcium concentration. Promotes intracelllular ROS generation and platelet particle formation (fragmentation) in vitro and in vivo .
Purification Methods
It recrystallises from Me2CO as colourless needles. Protect it from light and moisture, store in a refrigerator. It is soluble in Me2SO or EtOH and can be stored for 3 months without loss of activity. The Mg and Ca salts are soluble in organic solvents and cross biological membranes. It has a pKa of 6.9 in 90% Me2SO. The Ca complex crystallises from 50% EtOH as colourless prisms. It is highly TOXIC. [Pressman Ann Rev Biochem 45 501 1976, Chaney et al. J Am Chem Soc 96 1932 1974, Chaney et al. J Antibiotics 29 124 1976, Suzuki et al. Anal Biochem 61 382 1989, Simon & Carafoli Methods Enzymol 56 439 1977.]
A23187 Preparation Products And Raw materials
A23187 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| National Chemical Co. | 91-22-26871818 | Maharashtra, India | 60 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Alfa Chemistry | United States | 2344 | 58 | Inquiry | |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Beijing Taize Ruida Technology Co., Ltd. | 400-800-8151 13651185998 | CHINA | 6536 | 58 | Inquiry |
| Shenzhen Xinbosheng Biological Technology Co., Ltd. | 0755-26755892 | CHINA | 6164 | 58 | Inquiry |