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ChemicalBook > Product Catalogue >Analytical Chemistry >Analysis reagents >General Analytical Reagents >A23187

A23187

A23187 Structure
  • ₹4630.01 - ₹88570.15
  • Product name: A23187
  • CAS: 52665-69-7
  • MF: C29H37N3O6
  • MW: 523.62
  • EINECS:258-084-1
  • MDL Number:MFCD00151202
  • Synonyms:A 23187, CaliMycin;CalciuM Ionophore A23187, froM StreptoMyces chartreusis;Calcimycin [Calcium Ionophore A23187];4-Benzoxazolecarboxylicacid,5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-;4-BENZOXAZOLECARBOXYLIC ACID, 5-(METHYLAMINO)-2-((3,9,11-TRIMETHYL-8-(1-METHYL-2-OXO-2-(1H-PYRROL-2-YL)ETHYL)-1,7-DIOXASPIRO(5.5)UNDEC-2-YL)METHYL)-(6S-(6ALPHA(2S*,3S*),8BETA(R),9BETA,11ALPHA))-;5-(METHYLAMINO)-2-[[[2R,3R,6S,8S,9R,11R]-3,9,11-TRIMETHYL-8-[(1S)-1-METHYL-2-OXO-2-(1H-PYRROL-2-YL)-ETHYL]-1,7-DIOXASPIRO[5.5]UNDEC-2-YL]METHYL]-4-BENZOXAZOLECARBOXYLIC ACID;A23187;ANTIBIOTIC A23187
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  • Sigma-Aldrich(India)

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  • 1MG
  • 5MG
  • 10MG
  • 25MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product number100105
  • Product descriptionA23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem A mobile ion-carrier that forms stable complexes with divalent cations.
  • Packaging1MG
  • Price₹4630.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7522
  • Product descriptionCalcium Ionophore A23187 ≥98% (TLC), powder
  • Packaging1MG
  • Price₹6408.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number21186
  • Product descriptionCalcium ionophore III Selectophore?, function tested
  • Packaging5MG
  • Price₹11474.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number100105
  • Product descriptionA23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem A mobile ion-carrier that forms stable complexes with divalent cations.
  • Packaging5MG
  • Price₹12940
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7522
  • Product descriptionCalcium Ionophore A23187 ≥98% (TLC), powder
  • Packaging5MG
  • Price₹15165.83
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number100105
  • Product descriptionA23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem A mobile ion-carrier that forms stable complexes with divalent cations.
  • Packaging10MG
  • Price₹18830
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7522
  • Product descriptionCalcium Ionophore A23187 ≥98% (TLC), powder
  • Packaging10MG
  • Price₹24085.63
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number21186
  • Product descriptionCalcium ionophore III Selectophore?, function tested
  • Packaging25MG
  • Price₹41708.73
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number100105
  • Product descriptionA23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem A mobile ion-carrier that forms stable complexes with divalent cations.
  • Packaging50MG
  • Price₹66199.99
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7522
  • Product descriptionCalcium Ionophore A23187 ≥98% (TLC), powder
  • Packaging50MG
  • Price₹88570.15
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem A mobile ion-carrier that forms stable complexes with divalent cations. 1MG ₹4630.01 2022-06-14 Buy
Sigma-Aldrich(India) C7522 Calcium Ionophore A23187 ≥98% (TLC), powder 1MG ₹6408.4 2022-06-14 Buy
Sigma-Aldrich(India) 21186 Calcium ionophore III Selectophore?, function tested 5MG ₹11474.5 2022-06-14 Buy
Sigma-Aldrich(India) 100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem A mobile ion-carrier that forms stable complexes with divalent cations. 5MG ₹12940 2022-06-14 Buy
Sigma-Aldrich(India) C7522 Calcium Ionophore A23187 ≥98% (TLC), powder 5MG ₹15165.83 2022-06-14 Buy
Sigma-Aldrich(India) 100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem A mobile ion-carrier that forms stable complexes with divalent cations. 10MG ₹18830 2022-06-14 Buy
Sigma-Aldrich(India) C7522 Calcium Ionophore A23187 ≥98% (TLC), powder 10MG ₹24085.63 2022-06-14 Buy
Sigma-Aldrich(India) 21186 Calcium ionophore III Selectophore?, function tested 25MG ₹41708.73 2022-06-14 Buy
Sigma-Aldrich(India) 100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem A mobile ion-carrier that forms stable complexes with divalent cations. 50MG ₹66199.99 2022-06-14 Buy
Sigma-Aldrich(India) C7522 Calcium Ionophore A23187 ≥98% (TLC), powder 50MG ₹88570.15 2022-06-14 Buy

Properties

Melting point :187-190 °C
alpha :D25 -56° (c = 1 in chloroform)
Boiling point :710.3±55.0 °C(Predicted)
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO with warming or sonication. Also soluble in ethanol or ethyl acetate
form :Solid
pka :pKa1 6.9 in 90% DMSO
color :white to light yellow
Merck :13,1639
BRN :1096801
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 4 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

A-23187 is a divalent cation ionophore. While more selective for Mn2+, it is commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways. A-23187 is also used to produce apoptosis through calcium overload, as occurs during hypoxic or oxidative stress.

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