OLIGOMYCIN C

OLIGOMYCIN C Structure
CAS No.
11052-72-5
Chemical Name:
OLIGOMYCIN C
Synonyms
OLIGOMYCIN C;Oligmycin C;12-Deoxyoligomycin A;Oligomycin A, 12-deoxy-;OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
CBNumber:
CB4354053
Molecular Formula:
C45H74O10
Molecular Weight:
775.06
MOL File:
11052-72-5.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:02:36

OLIGOMYCIN C Properties

Boiling point 876.2±65.0 °C(Predicted)
Density 1.091 g/cm3
storage temp. −20°C
solubility Soluble in DMSO
form White to off-white powder.
pka 13.49±0.70(Predicted)
Merck 13,6902

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P271
Hazard Codes  Xn
Risk Statements  22
RIDADR  2811
RTECS  RK3335000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2941900000
Toxicity LD50 ipr-mus: 8300 mg/kg JACSAT 80,6092,1958
NFPA 704
0
2 0

OLIGOMYCIN C Chemical Properties,Uses,Production

Description

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F1FO-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.

Uses

Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.

Safety Profile

A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors

OLIGOMYCIN C Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 75)Suppliers
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TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
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Fluorochem Ltd. +44 1457 868921 United Kingdom 6406 74 Inquiry
MP Biomedicals, Inc. 949 833 2500 United States 6566 81 Inquiry
12-Deoxyoligomycin A Oligmycin C OLIGOMYCIN C OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES Oligomycin A, 12-deoxy- Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)- Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)- 11052-72-5 11053-72-5 C45H74O10 Antibiotics A to Z Antibiotics N-S BioChemical Antibiotics Antibiotics Antibiotics A to Antibiotics by Application Antibiotics N-SAntibiotics AntifungalAntibiotics Antineoplastic and Immunosuppressive AntibioticsAntibiotics Chemical Structure Class Inhibits an EnzymeAntibiotics Macrolides Mechanism of Action Spectrum of Activity