Indole-3-carboxylic acid
![Indole-3-carboxylic acid Structure](CAS/GIF/771-50-6.gif)
- CAS No.
- 771-50-6
- Chemical Name:
- Indole-3-carboxylic acid
- Synonyms
- 1H-INDOLE-3-CARBOXYLIC ACID;ICO;3-Indoleformic acid;e-3-carboxyL;3-Indoleformic;3-CARBOXYINDOLE;3-indoleic acid;3-Indolecarboxylic;Indol-3-carbonsure;Indole-3-carboxylic
- CBNumber:
- CB4416867
- Molecular Formula:
- C9H7NO2
- Molecular Weight:
- 161.16
- MOL File:
- 771-50-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/13 17:19:14
Melting point | 232-234 °C (dec.)(lit.) |
---|---|
Boiling point | 287.44°C (rough estimate) |
Density | 1.2480 (rough estimate) |
refractive index | 1.5050 (estimate) |
storage temp. | 2-8°C |
solubility | Soluble in 95% Ethanol: 50 mg/ml, also soluble in methanol. |
form | Powder |
pka | 3.90±0.10(Predicted) |
color | Light beige |
BRN | 129435 |
InChIKey | KMAKOBLIOCQGJP-UHFFFAOYSA-N |
CAS DataBase Reference | 771-50-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Hazard Codes | Xn,Xi | |||||||||
Risk Statements | 36/37/38-21/22 | |||||||||
Safety Statements | 22-24/25-36/37/39-26 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | NK7882892 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
|
Indole-3-carboxylic acid price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 284734 | Indole-3-carboxylic acid ReagentPlus?, 99% | 771-50-6 | 1G | ₹2413.98 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 284734 | Indole-3-carboxylic acid ReagentPlus?, 99% | 771-50-6 | 5G | ₹7003.78 | 2022-06-14 | Buy |
TCI Chemicals (India) | I0028 | Indole-3-carboxylic Acid | 771-50-6 | 5G | ₹4000 | 2022-05-26 | Buy |
TCI Chemicals (India) | I0028 | Indole-3-carboxylic Acid | 771-50-6 | 25G | ₹13800 | 2022-05-26 | Buy |
ottokemi | I 1314 | Indole-3-carboxylic acid 99% | 771-50-6 | 1gm | ₹603 | 2022-05-26 | Buy |
Indole-3-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
light beige crystalline powder (recrystallized from acetate-petroleum ether). Soluble in ethanol, ether, acetate, insoluble in boiling water, benzene, insoluble in petroleum ether.
Application
Indole-3-carboxylic Acid is a specific and competitive inhibitor of the potentiation of glycine of NMDA-gated current. Chemical reagent in the synthesis of thiadiazole derivatives used for anticancer activity.
Definition
ChEBI: Indole-3-carboxylic acid is an indole-3-carboxylic acid carrying a carboxy group at position 3. It has a role as a human metabolite and a bacterial metabolite. It is a conjugate acid of an indole-3-carboxylate.
Preparation
indole-3-carboxylic acid can be synthesized by the hydrolysis reaction of 3-trichloroacetyl indole: add 235g 3-trichloroacetyl indole into 1000ml methanol, slowly drop an appropriate amount of 50% KOH solution, heat up and reflux for 18 hours, cool to room temperature, The methanol was recovered by concentration, and the residual liquid was left; 1500 ml of water was added to the residual liquid, hydrochloric acid was added dropwise to adjust pH=3~4, and then filtered, and the solid obtained by filtration was dried to obtain 144g of indole-3-carboxylic acid crude product; The crude product was slurried with 100g of ethyl acetate for 25 minutes,filtered and dried to obtain indole-3-carboxylic acid (137g, yield 91.8%).
General Description
The structures of the derivatives of indole-3-carboxylic acid were studied using gas chromatography with high resolution mass spectrometry (GC-HRMS), ultra-high performance liquid chromatography in combination with high resolution tandem mass spectrometry (UHPLC-HRMS), nuclear magnetic resonance spectroscopy (NMR) and Fourier transform infrared spectroscopy (FT-IR).
Indole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
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Supplier | Advantage |
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ANJI BIOSCIENCES | 58 |
anjali labs | 58 |
DeFINE CHEMICALS | 58 |
Montage Chemicals Pvt Ltd | 58 |
CiVentiChem Private Limited | 58 |
Trignokem International | 50 |
TCI Chemicals (India) Pvt. Ltd. | 58 |
A.J Chemicals | 58 |
Otto Chemie Pvt. Ltd. | 58 |
Alfa Aesar | 58 |