ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Thiol / thiol >4'-Methylthioacetophenone
4'-Methylthioacetophenone
![4'-Methylthioacetophenone Structure](CAS/GIF/1778-09-2.gif)
- CAS No.
- 1778-09-2
- Chemical Name:
- 4'-Methylthioacetophenone
- Synonyms
- Ethanone, 1-[4-(methylthio)phenyl]-;4-(METHYLTHIO)ACETOPHENONE;4-(Methyl thio);p-Acetylthioanisole;4'-Methylthioacetoph;Glycerol Impurity 24;4-(ACETYL)THIOANISOLE;Etoricoxib Impurity 61;4-THIOMETHYLACETOPHENONE;4'-Methylthioacetophenone
- CBNumber:
- CB4454274
- Molecular Formula:
- C9H10OS
- Molecular Weight:
- 166.24
- MOL File:
- 1778-09-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/4/23 13:52:06
Melting point | 80-82 °C(lit.) |
---|---|
Boiling point | 135 °C |
Density | 1.1369 (rough estimate) |
refractive index | 1.5600 (estimate) |
Flash point | 135°C/1mm |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform, Methanol |
form | Solid |
color | White to Off-White |
BRN | 1860517 |
CAS DataBase Reference | 1778-09-2(CAS DataBase Reference) |
NIST Chemistry Reference | 4-CH3S-C6H4-COCH3(1778-09-2) |
EPA Substance Registry System | 4'-(Methylmercapto)acetophenone (1778-09-2) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Irritant | |||||||||
HS Code | 29309099 | |||||||||
NFPA 704 |
|
4'-Methylthioacetophenone price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 396583 | 4′-(Methylthio)acetophenone 97% | 1778-09-2 | 1G | ₹1948.5 | 2022-06-14 | Buy |
TCI Chemicals (India) | M1672 | 4'-(Methylthio)acetophenone min. 98.0 % | 1778-09-2 | 5G | ₹3800 | 2022-05-26 | Buy |
TCI Chemicals (India) | M1672 | 4'-(Methylthio)acetophenone min. 98.0 % | 1778-09-2 | 25G | ₹9700 | 2022-05-26 | Buy |
4'-Methylthioacetophenone Chemical Properties,Uses,Production
Chemical Properties
White to light yellow crystal powde
Uses
4′-(Methylthio)acetophenone may be used for the synthesis of Vioxx (Rofecoxib), an non-steroidal anti-inflammatory drug (NSAID). It may be used in the synthesis of (E)-1-[4-(methylsulfanyl)phenyl]-3-phenylprop-2-en-1-one.
General Description
4′-(Methylthio)acetophenone (4-(Methylthio)acetophenone, p-(methylthio) acetophenone, 4-MTAP) is a sulphur containing organic building block. It is a key intermediate in drug synthesis. Its industrial preparation, via Friedel-Crafts acylation reaction in the presence of aluminium chloride as catalyst and acetyl chloride as acylating agent has been reported. It has been prepared by the acetylation reaction of thioanisole with acetic anhydride in the presence of solid acid catalyst.
4'-Methylthioacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 249)Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
Bhavesh Chem Labs | +91 9182312179 | Telangana, India | 322 | 58 | Inquiry |
VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
Swadev Chemicals | +91-9898998064 +91-7203031021 | Gujarat, India | 19 | 58 | Inquiry |
Karvy Therapeutics Pvt Ltd | +91-9824044913 +91-9824044913 | Gujarat, India | 10 | 58 | Inquiry |
SANIKA CHEMICALS PVT.LTD. | +091-22-27572545/27570607 | NaviMumbai, India | 38 | 58 | Inquiry |
Oceanic Pharmachem Pvt., Ltd. (OPPL) | 91-22-42128600 | Maharashtra, India | 947 | 58 | Inquiry |
Karvy Therapeutics Pvt. Ltd. | 91-281-2783375 | Gujarat, India | 7 | 58 | Inquiry |
Swadev Chemicals | 91-9898998064 | Gujarat, India | 19 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Supplier | Advantage |
---|---|
GLR Innovations | 58 |
Bhavesh Chem Labs | 58 |
VGS SYNTHESIS PRIVATE LIMITED | 58 |
Swadev Chemicals | 58 |
Karvy Therapeutics Pvt Ltd | 58 |
SANIKA CHEMICALS PVT.LTD. | 58 |
Oceanic Pharmachem Pvt., Ltd. (OPPL) | 58 |
Karvy Therapeutics Pvt. Ltd. | 58 |
Swadev Chemicals | 58 |
CLEARSYNTH LABS LTD. | 58 |
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