Sobuzoxane
- CAS No.
- 98631-95-9
- Chemical Name:
- Sobuzoxane
- Synonyms
- e)(ester);Sobuzoxane;Perazoline;Sobuzoxane/MST 16;methylpropyl)ester;1,2-bis(4-isobutoxycarbonyloxymethyl-3,5-dioxo-piperazin-1-yl)ethane;4,4’-ethylenebis(1-(hydroxymethyl)-2,6-piperazinedione)bis(isobutylcarbonat;1,2-ethanediylbis((2,6-dioxo-4,1-piperazinediyl)methylene)bis(2-carbonicaci;4,4'-Ethylenebis(2,6-dioxopiperazine-1-methanol)bis(2-methylpropoxyformate);MST-16, 4,4μ-(1,2-Ethanediyl)bis(1-isobutoxycarbonyloxmethyl-2,6-piperazinedione)
- CBNumber:
- CB4498395
- Molecular Formula:
- C22H34N4O10
- Molecular Weight:
- 514.53
- MOL File:
- 98631-95-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/4/17 18:22:24
SAFETY
Risk and Safety Statements
| WGK Germany | 2 |
|---|---|
| RTECS | FG1582500 |
| Toxicity | LD50 in male, female mice, rats (mg/kg): 807, 960, 877, 567 i.p.; 400, 673, 3025, 2821 s.c.; >5 g/kg orally in all species (Tokiwa) |
Sobuzoxane Chemical Properties,Uses,Production
Description
Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.
Uses
Sobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.
Sobuzoxane Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49732 | 58 | Inquiry |
| Aladdin Scientific | United States | 52924 | 58 | Inquiry | |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | China | 5237 | 58 | Inquiry |
| Absin Bioscience Inc. | 021-38015121-8802 | CHINA | 6208 | 58 | Inquiry |
| United States Biological | 800.520.3011 or 781.639.5092 | United States | 6214 | 80 | Inquiry |
| Waterstone Technology, LLC | 317 644 0862 | United States | 6786 | 30 | Inquiry |
| SIGMA-RBI | 800 736 3690 (Orders) | Switzerland | 6896 | 91 | Inquiry |
| Santa Cruz Biotechnology, Inc. | +1 (831) 457-3800 | United States | 3597 | 60 | Inquiry |
| Alfa Chemistry | +1 (201) 478-8534 | United States | 6814 | 0 | Inquiry |
| Riedel-de Haen AG | 800 558-9160 | United States | 6773 | 87 | Inquiry |
| Supplier | Advantage |
|---|---|
| CONIER CHEM AND PHARMA LIMITED | 58 |
| Aladdin Scientific | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 58 |
| Absin Bioscience Inc. | 58 |
| United States Biological | 80 |
| Waterstone Technology, LLC | 30 |
| SIGMA-RBI | 91 |
| Santa Cruz Biotechnology, Inc. | 60 |
| Alfa Chemistry | 0 |
| Riedel-de Haen AG | 87 |
98631-95-9(Sobuzoxane)Related Search:
1of3
chevron_right