6-Chloronicotinic acid
- CAS No.
- 5326-23-8
- Chemical Name:
- 6-Chloronicotinic acid
- Synonyms
- 2－chloro－5－pyrdinecarboxylic acid;2-chloropyridine-5-carboxylic acid;6-CHLOROPYRIDINE-3-CARBOXYLIC ACID;6-ChL;6-Chloronicoti;TIMTEC-BB SBB004004;RARECHEM AL BO 0729;6 - chlorine niacin;6-Chloronicotinic ac;2-Chloroncotinic acid
- CBNumber:
- CB4707499
- Molecular Formula:
- C6H4ClNO2
- Molecular Weight:
- 157.55
- MOL File:
- 5326-23-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/9/24 13:23:39
| Melting point | 190 °C (dec.)(lit.) |
|---|---|
| Boiling point | 241.15°C (rough estimate) |
| Density | 0.5 |
| refractive index | 1.5870 (estimate) |
| Flash point | 192°C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | deionized water: soluble |
| pka | 3.24±0.10(Predicted) |
| form | Crystalline Powder |
| color | Off-white to beige |
| Water Solubility | Soluble in water (2 mg/ml at 20°C), ethanol, methanol, DMSO, and slightly soluble in chloroform. |
| Decomposition | 192 ºC |
| BRN | 115993 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | UAWMVMPAYRWUFX-UHFFFAOYSA-N |
| CAS DataBase Reference | 5326-23-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 6-Chloronicotinic acid(5326-23-8) |
| EPA Substance Registry System | 6-Chloronicotinic acid (5326-23-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | T | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333999 | |||||||||
| NFPA 704 |
|
6-Chloronicotinic acid price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 156353 | 6-Chloropyridine-3-carboxylic acid 99% | 5326-23-8 | 5G | ₹2576.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 68678 | 6-Chloropyridine-3-carboxylic acid PESTANAL?, analytical standard | 5326-23-8 | 100MG | ₹4200.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 156353 | 6-Chloropyridine-3-carboxylic acid 99% | 5326-23-8 | 25G | ₹6430.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 156353 | 6-Chloropyridine-3-carboxylic acid 99% | 5326-23-8 | 100G | ₹15750.38 | 2022-06-14 | Buy |
| ALFA India | ALF-A15620-22 | 6-Chloronicotinic acid, 99% | 5326-23-8 | 100g | ₹23688 | 2022-05-26 | Buy |
6-Chloronicotinic acid Chemical Properties,Uses,Production
Chemical Properties
Off-white to beige crystalline powder
Uses
6-Chloronicotinic acid is used as building block for different chemical synthesis. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.
Definition
ChEBI: 6-Chloronicotinic acid is a member of pyridines and an aromatic carboxylic acid.
General Description
6-Chloropyridine-3-carboxylic acid is a metabolite of the neonicotinoid pesticides, imidacloprid and acetamiprid and occurs in different environmental matrices.(3) It is widely used in agricultural crop protection, domestic insect control and environmental pest management.
Synthesis
In a 1000ml flask, add 450g chlorobenzene, 100g 2-chloro-5-methylpyridine, and 3g catalyst cobalt acetate under stirring, heat the system to 80℃, introduce oxygen, and control the oxygen flow rate at 0.4L/min. React under this condition for 4 hours. After the reaction, cool the system to room temperature, filter, and dry to obtain a mixture of 119g 6-chloronicotinic acid and cobalt acetate. Place those mentioned above mixed crude product in a 1000ml flask, add 600g of recrystallization solvent methanol, stir and heat to reflux; wait for the 6-chloronicotinic acid crude product to dissolve completely, keep warm for 5min, slowly cool the system to 5℃, precipitate a white product, maintain this internal temperature and continue stirring for 1 hour, filter, wash the filter cake once with a small amount of cooled methanol, and dry the obtained damp product at 80℃ for 4 hours to obtain 98.5g 6-chloronicotinic acid, purity 99.52% (HPLC), yield 79.7%.
Purification Methods
Purify it by recrystallisation from hot H2O and sublime it in a vacuum. [Pechmann & Welsch Chem Ber 17 2384 1884, Herz & Murty J Org Chem 26 122 1961, Beilstein 22/2 V 177.]
6-Chloronicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
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| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| ANJI BIOSCIENCES | 58 |
| TANUJ PYRIDINE | 58 |
| Varna Chems | 58 |
| CHATURYA BIOTECH | 58 |
| Arown Pharma | 58 |
| VGS SYNTHESIS PRIVATE LIMITED | 58 |
| JSK Chemicals | 58 |
| Sintilla Medcoms Pvt Ltd | 58 |
| ARR Life Sciences | 58 |
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