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Trilostane

Trilostane Structure
CAS No.
13647-35-3
Chemical Name:
Trilostane
Synonyms
Vetoryl;Desopan;modrenal;Modrefen;Trostan*;Win 24540;rilostane;Trilostan;TRILOSTANE;Modrastane
CBNumber:
CB4768762
Molecular Formula:
C20H27NO3
Molecular Weight:
329.43
MOL File:
13647-35-3.mol
MSDS File:
SDS
Modify Date:
2024/9/3 18:36:42

Trilostane Properties

Melting point 264 °C
alpha D25 +137.4° (c = 1 in pyridine)
Boiling point 467.02°C (rough estimate)
Density 1.1213 (rough estimate)
refractive index 1.5614 (estimate)
storage temp. 2-8°C
solubility DMSO: ≥17mg/mL
form powder
pka 8.57±0.70(Predicted)
color white to tan
InChIKey KVJXBPDAXMEYOA-CXANFOAXSA-N
SMILES [C@@]123CC[C@@]4([H])[C@]5([H])CC[C@H](O)[C@@]5(C)CC[C@]4([H])[C@@]1(C)CC(C#N)=C(O)[C@@]2([H])O3 |&1:0,3,5,9,11,15,17,25,r|
CAS DataBase Reference 13647-35-3(CAS DataBase Reference)
EPA Substance Registry System Trilostane (13647-35-3)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H315-H319-H361
Precautionary statements  P201-P302+P352-P305+P351+P338-P308+P313
Hazard Codes  Xi
Risk Statements  36/37/38-62
Safety Statements  26-36/37
WGK Germany  3
HS Code  29372900
NFPA 704
0
2 0

Trilostane price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0141 Trilostane ≥98% (HPLC) 13647-35-3 10MG ₹12849.28 2022-06-14 Buy
Sigma-Aldrich(India) SML0141 Trilostane ≥98% (HPLC) 13647-35-3 50MG ₹53475.5 2022-06-14 Buy
Product number Packaging Price Buy
SML0141 10MG ₹12849.28 Buy
SML0141 50MG ₹53475.5 Buy

Trilostane Chemical Properties,Uses,Production

Description

3β-hydroxysteroid dehydrogenase (3β-HSD) type 1 and type 2 isoforms are key enzymes for the biosynthesis of all active steroid hormones. 3β-HSD1 (type I) is expressed in placenta and peripheral tissues including breast tumors, whereas 3β-HSD2 (type 2) is expressed in the adrenal gland, ovary, and testis. Trilostane is an inhibitor of the 3β-HSDs: 3β-HSD1 and 3β-HSD2 with Ki values of 0.10 and 1.60 μM, respectively. Trilsotane has been approved for use in the treatment of Cushing’s syndrome in dogs to reduce cortisol, aldosterone, and corticosterone levels. Because human 3β-HSD (type 1) is a critical enzyme in the conversion of DHEA to estradiol in breast tumors, trilostane is also of interest for the treatment of breast cancer in postmenopausal women.

Chemical Properties

Tan Crystals

Uses

Trilostane has been used to evaluate its capability to regulate the sex-dependent differences in the lipopolysaccharide (LPS)-induced inflammatory responses of astrocytes.

General Description

Trilostane inhibits the production of adrenal steroids, such as cortisol and aldosterone. It is used to treat aldosteronism.

Trilostane Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 354)Suppliers
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Meenaakshi Molecules Pvt Ltd +91-9121311126 +91-9121311126 Telangana, India 45 58 Inquiry
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Shaanxi Haibo Biotechnology Co., Ltd +undefined18602966907 China 1000 58 Inquiry

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Trilostane Spectrum

TRILOSTANE (2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car 17-beta)-ph (4a,5a,17b)-3,17-Dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile 5a-Androstane-2a-carbonitrile, 4a,5-epoxy-17b-hydroxy-3-oxo- Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4a,5a,17b)- 4α,5-Epoxy-3,17β-dihydroxy-5α-androst-2-ene-2-carbonitrile 4α,5-Epoxy-3,17β-dihydroxy-5α-androstan-2-ene-2-carbonitrile Trilostane ,99% modrenal Win-24540,Desopan,Modrastane,Modrenal 4,5-Epoxy-5H-cyclopenta[a]phenanthrene, androst-2-ene-2-carbonitrile deriv. Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4a,5a,17b)- (9CI) Desopan Modrastane Modrefen Win 24540 (1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-diMethyl-7-oxapentacyclo[9.7.0.0^{2,8}.0^{6,8}.0^{12,16}]octadec-4-ene-4-carbonitrile Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4α,5α,17β)- (4α,5α,17β)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile 4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril 4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile 4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al Trilostane(Win 24540 MODRASTANE; MODREFEN; MODRENAL; VETORYL; WIN 24540 Trilostane (Mixture of Tautomeric Isomers) rilostane Trilostane ISO 9001:2015 REACH Trilostan Vetoryl Tralostatin Trilostane/Win24540/Modrastane (1aS,4aR,4bS,6aS,7S,9aS,9bS,11aR)-2,7-Dihydroxy-4a,6a-dimethyl-1a,4,4a,4b,5,6,6a,7,8,9,9a,9b,10,11-tetradecahydrocyclopenta[7,8]phenanthro[1,10a-b]oxirene-3-carbonitrile Trostan* Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4α,5α,17β)- 13647-35-3 3647-35-3 Intermediates & Fine Chemicals Pharmaceuticals Steroids Inhibitor FULVICIN APIs