Isoamyl nitrite
- CAS No.
- 110-46-3
- Chemical Name:
- Isoamyl nitrite
- Synonyms
- ISOPENTYL NITRITE;AMYL NITRITE;amyl;3-METHYLBUTYL NITRITE;Aspiral;Isopentyl alcohol, nitrite;Vaporole;Amilnitrit;amylnitrit;NCI-C50179
- CBNumber:
- CB2226055
- Molecular Formula:
- C5H11NO2
- Molecular Weight:
- 117.15
- MOL File:
- 110-46-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/12/18 14:07:02
| Boiling point | 99 °C(lit.) |
|---|---|
| Density | 0.872 g/mL at 25 °C(lit.) |
| vapor pressure | 35-59.995hPa at 20-25℃ |
| refractive index |
n |
| Flash point | 50 °F |
| storage temp. | Store at +15°C to +25°C. |
| solubility | Chloroform (Soluble), Methanol (Slightly) |
| form | Liquid |
| color | Clear yellow |
| Water Solubility | <0.01 g/100 mL at 18 ºC |
| Sensitive | Air & Light Sensitive |
| Merck | 14,5123 |
| BRN | 969510 |
| Stability | Unstable. Air and light sensitive. Flammable. Forms explosive mixtures with air or oxygen. Incompatible with oxidizing agents, reducing agents. |
| InChIKey | OWFXIOWLTKNBAP-UHFFFAOYSA-N |
| LogP | 2.45-2.85 |
| CAS DataBase Reference | 110-46-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Amyl Nitrite(110-46-3) |
| EPA Substance Registry System | Isoamyl nitrite (110-46-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS02,GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H302+H332-H314-H317-H341 | |||||||||
| Precautionary statements | P210-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | F,Xn | |||||||||
| Risk Statements | 11-20/22 | |||||||||
| Safety Statements | 16-24-46 | |||||||||
| RIDADR | UN 1113 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | NT0187500 | |||||||||
| F | 1-8-9 | |||||||||
| Autoignition Temperature | 208 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29209090 | |||||||||
| Hazardous Substances Data | 110-46-3(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in Rabbit: 505 mg/kg | |||||||||
| NFPA 704 |
|
Isoamyl nitrite price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 150495 | Isopentyl nitrite 96% | 110-46-3 | 5ML | ₹2435.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 150495 | Isopentyl nitrite 96% | 110-46-3 | 100ML | ₹2846.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 150495 | Isopentyl nitrite 96% | 110-46-3 | 500ML | ₹9850.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 1.01245 | Isopentyl nitrite extra pure stabilized with potassium carbonate | 110-46-3 | 250ML | ₹25060.01 | 2022-06-14 | Buy |
| TCI Chemicals (India) | I0089 | Isoamyl Nitrite min. 95.0 % | 110-46-3 | 25ML | ₹1900 | 2022-05-26 | Buy |
Isoamyl nitrite Chemical Properties,Uses,Production
Description
Amyl nitrite had been used clinically as early as 1867, when the Scottish physician Sir Thomas Brunton used it as a vasodilator as treatment for angina pectoris in his patients. In the late 1880s, a protective effect on cyanide toxicity in canines was noted when amyl nitrite was inhaled postexposure. Amyl nitrite has been used clinically in a multicomponent cyanide antidote kit and is also a recreational drug of abuse (‘poppers’).
Chemical Properties
Isoamyl Nitrite is flammable and explosive and decomposes when exposed to air and sunlight.
Chemical Properties
Amyl nitrites are flammable, yellowish liquid with a penetrating, fruity odor. Sp.Gr. 0.88. B.P. 99℃. Slightly soluble in water, miscible with alcohol and oils.
Uses
Isoamyl nitrite is a light yellow, transparent liquid with a
pleasant, fragrant, fruity odor. Amyl nitrite was introduced to
medicine in 1859 and has been under considerable pharmacological
investigation since that time. Its major use was for
treating angina pectoris through its vasodilative effect on the
coronary arteries. However, this effect is transient, and
nitroglycerin and longer acting nitrates have largely replaced
it. Amyl nitrite has been most helpful in clarifying the
differential diagnosis of murmurs. For example, left ventricular
outflowobstruction increases followingamyl nitrite administration.
Mitral regurgitation decreases following amyl nitrite
as does the apical diastolic rumble of mitral stenosis. The
Austin–Flint rumble decreases followingamyl nitrite as does a
ventricular septal defect and acyanotic tetralogy of Fallot. Pulmonic stenosis increases as does isolated valvular pulmonary
stenosis following amyl nitrite.
Isoamyl nitrite has also been reportedly used for inhalation
abuse. The symptoms following inhalation of
large doses by humans are flushing of the face, pulsatile
headache, disturbing tachycardia, cyanosis (methemoglobinemia),
weakness, confusion, restlessness, faintness, and
collapse, particularly if the individual is standing. The
symptoms are usually of short duration. Industrial intoxication
has not been reported.
Definition
ChEBI: Isoamyl nitrite is a nitrite ester having isopentyl as the alkyl group. It has a role as a vasodilator agent and an antihypertensive agent. It derives from an isoamylol.
Preparation
Isoamyl nitrite is produced from iso-Amyl alcohol, Sodium nitrite, water and diluted Sulfuric acid.
General Description
Clear yellow liquid.
Air & Water Reactions
Highly flammable. Decomposes on exposure to air and light. Insoluble in water.
Reactivity Profile
Isoamyl nitrite is an oxidizing agent but can serve as a reducing agent. Forms explosive mixtures with air or oxygen. .
Hazard
Flammable, dangerous fire risk, a strong oxidizer. Vapor may explode if ignited.
Fire Hazard
Isoamyl nitrite is flammable.
Potential Exposure
Amyl nitrite is used to make pharmaceuticals; perfumes, diazonium compounds, and other chemicals.
Environmental Fate
The primary mechanism of toxicity develops from the
powerful oxidative effects of nitrites on hemoglobin. Methemoglobinemia,
which develops when the iron atom in
hemoglobin loses one electron to an oxidant, causing a change
from the ferrous (2+) state to the ferric (3+) state, may cause
cellular hypoxia. When methemoglobin levels exceed
10–15%, cyanosis may be evident. Nitrites also cause vasodilation
by direct action on smooth muscle. Physical effects
include decreases in blood pressure, headache, flushing of the
face, increased heart rate, dizziness, and relaxation of involuntary
muscles, especially of the blood vessels and the anal
sphincter.
Amyl nitrite may be irritating to the lungs and throat when
breathed in. With exposure to the skin, amyl nitrite has irritant
properties. It can also be readily absorbed, causing systemic
effects with skin contact.
Shipping
UN1993 Flammable liquids, n.o.s., Hazard Class: 3; Labels: 3-Flammable liquid, Technical Name Required.
Incompatibilities
Vapors may form explosive mixture with air. Slowly decomposes in light, heat, and on contact with water. A strong oxidizer. Contact with reducing agents and easily oxidizable materials may cause fire and explosions. Reported to be an explosion hazard when exposed to air and light. Keep away from alcohols, antipyrine, alkaline materials; alkaline carbonates; potassium iodide; bromides, and ferrous salts. Attacks metals in the presence of moisture.
Waste Disposal
Incineration with scrubber to remove nitrogen oxides from the combustion gases.
Isoamyl nitrite Preparation Products And Raw materials
Raw materials
Preparation Products
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