Chloroacetic anhydride
- CAS No.
- 541-88-8
- Chemical Name:
- Chloroacetic anhydride
- Synonyms
- 2-Chloroacetic anhydride;Monochloroacetic anhydride;CHLOROACETIC ACID ANHYDRIDE;MONOCHLOROACETIC ACID ANHYDRIDE;NSC 71207;oroacetic anhydride;chloraceticanhydride;Chloracetic anhydride;chloroacetylanhydride;CHLOROACETIC ANHYDRIDE
- CBNumber:
- CB4853783
- Molecular Formula:
- C4H4Cl2O3
- Molecular Weight:
- 170.97
- MOL File:
- 541-88-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/8/23 18:01:39
| Melting point | 51 °C |
|---|---|
| Boiling point | 203 °C |
| Density | 1.449 |
| vapor pressure | <0.75 mm Hg ( 20 °C) |
| refractive index | 1.4730 (estimate) |
| Flash point | >230 °F |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Freely soluble in ether, chloroform. Slightly soluble in benzene. Insoluble in cold ligroin |
| form | Crystals, Chunks or Low Melting Mass |
| color | brown |
| Sensitive | Moisture Sensitive |
| Merck | 14,2113 |
| BRN | 774533 |
| Stability | Moisture Sensitive |
| InChIKey | PNVPNXKRAUBJGW-UHFFFAOYSA-N |
| CAS DataBase Reference | 541-88-8(CAS DataBase Reference) |
| EPA Substance Registry System | Acetic acid, chloro-, anhydride (541-88-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H314 | |||||||||
| Precautionary statements | P260-P270-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | C,T | |||||||||
| Risk Statements | 34-36/37-43-25 | |||||||||
| Safety Statements | 26-28-36/37/39-45-27 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-19-21 | |||||||||
| Hazard Note | Highly Toxic/Corrosive/Lachrymator | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29159000 | |||||||||
| NFPA 704 |
|
Chloroacetic anhydride price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ALFA India | ALF-A14015-36 | Chloroacetic anhydride, 97% | 541-88-8 | 500g | ₹35636 | 2022-05-26 | Buy |
| ALFA India | ALF-A14015-22 | Chloroacetic anhydride, 97% | 541-88-8 | 100g | ₹8795 | 2022-05-26 | Buy |
| ALFA India | ALF-A14015-14 | Chloroacetic anhydride, 97% | 541-88-8 | 25g | ₹3325 | 2022-05-26 | Buy |
Chloroacetic anhydride Chemical Properties,Uses,Production
Chemical Properties
brownish semi-transparent crystals, chunks or low
Uses
Chloroacetic anhydride has been used in the synthesis of 3,3-bis(sulfonato)-4,4-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive and photo-switchable cross-linker, D,L-7-azatryptophan, 2-methyl-[3,4-di-O-acetyl-6-O-(chloroacetyl)-1,2-dideoxy-α-D-glucopyrano]-[2,1:4,5]-2-oxazoline.
Preparation
chloroacetic anhydride Synthesis: Powdered s odium monochloroacetate(113.3g, 1.138 mol) was added slowly for a period of 15 min at room temperature (which slowly raises to 60°C) to a stirred solution of commercially available chloroaceyl chloride (127.5g, 1mol) in dry benzene (136mL) was refluxed for 9h. Salts were filtered off, the filtrate was cooled to room temperature, diluted with n-hexane and further cooled to 0°C. The solid separated was then filtered, washed with dry hexane and dried to yield chloroacetic anhydride as white crystalline compound in 60% yield (80g); mp=46-49°C [Lit. mp=46°C]. Alternatively, the benzene layer was directly subjected to high vacuum distillation.The product collected at 109-10°C at 10mm vacuum on cooling chloroacetic anhydride in lump form in 70 % yield (93g). It was observed that, the latter method gives anhydride in lump form while the former method gives in crystalline form.
Purification Methods
Crystallise the it from *benzene. [Eglinton et al. J Chem Soc 1860 1954, Beilstein 2 IV 487.]
Chloroacetic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
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|---|---|---|---|---|---|
| Biokemix | +91 (40) 6662-6366 | New Delhi, India | 487 | 50 | Inquiry |
| Valentis laboratories Pvt. Ltd. | 91-9391124464 | Hyderabad, India | 6 | 58 | Inquiry |
| SPB Pharma Chiemimpex | 91-9043046289 | Tamil Nadu, India | 94 | 58 | Inquiry |
| Moltus Research Laboratories | 91-9158275030 | Maharashtra, India | 9 | 58 | Inquiry |
| Innovative | 07942565925 | Mumbai, India | 617 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | China | 1000 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21673 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29897 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Biokemix | 50 |
| Valentis laboratories Pvt. Ltd. | 58 |
| SPB Pharma Chiemimpex | 58 |
| Moltus Research Laboratories | 58 |
| Innovative | 58 |
| Alfa Aesar | 58 |
| Hebei Mojin Biotechnology Co., Ltd | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | 58 |
| Henan Tianfu Chemical Co.,Ltd. | 55 |
| career henan chemical co | 58 |
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