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Dabigatran etexilate

Dabigatran etexilate Structure
CAS No.
211915-06-9
Chemical Name:
Dabigatran etexilate
Synonyms
DL-;BIBR-1048;N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMidino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridyl-beta-alanine,ethyl ester;Etexilate;Dabigatran ester;BIBR-1048 (Dabigatran);N-[2-[4-[N-(Hexyloxycarbonyl)aMidino]phenylaMinoMethyl]-1-Methyl-1H-benziMidazol-5-ylcarbonyl]-N-(2-;CS-62;Prazaxa;BIBR 1048
CBNumber:
CB62485052
Molecular Formula:
C34H41N7O5
Molecular Weight:
627.73
MOL File:
211915-06-9.mol
Modify Date:
2023/10/11 9:56:29
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Dabigatran etexilate Properties

Melting point 128-129°
Density 1.24±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly)
pka 9.88±0.46(Predicted)
form Solid
color White to Pale Yellow
Stability Hygroscopic

Dabigatran etexilate Chemical Properties,Uses,Production

Description

Dabigatran etexilate is an orally administered pro-drug of dabigatran, which is a direct inhibitor of thrombin and a potent anticoagulant. The serine protease thrombin is the final mediator in the coagulation cascade that leads to the production of fibrin, the main protein component of blood clots. Thrombin is also a potent activator of platelets. Consequently, thrombin inhibitors have found utility as anticoagulants in treating arterial and venous thrombosis. Warfarin, although orally available, has a narrow therapeutic index and requires frequent monitoring and dosage adjustment. Low-molecular-weight heparins provide better safety profile and less inter-patient variability; however, these agents are only available for parenteral administration. Direct thrombin inhibitors (DTIs) are a new class of anticoagulants that act by directly binding to thrombin at its catalytic or fibrinogen-binding sites, or both. Unlike the heparins, DTIs do not require the activation of secondary factors such as antithrombin to derive their activity, which makes their action more predictable. In addition, their ability to inhibit both free and clot-bound thrombin predisposes them for enhanced anticoagulation effect.

Uses

Dabigatran Etexilate is an oral anticoagulant and direct thrombin inhibitor.

Definition

ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-{N'-[(hexyloxy)carbonyl]carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amino group of thyl N-pyridin-2-yl-beta-alaninate. A prodrug for dabigatran, a thrombin inhibitor and anticoagulant which is used for the prevention of stroke and systemic embolism.

Dabigatran etexilate Preparation Products And Raw materials

Raw materials

C3-NITRO-4-METHYLAMINO-BENZOYLCHLORIDE HEXYL CHLOROFORMATE 4-(METHYLAMINO)-3-NITROBENZOIC ACID 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER
N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate Dabigatran iMpurity O ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE
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Preparation Products

Dabigatran Impurity 8 Dabigatran Etexilate Mesylate

Dabigatran etexilate Suppliers

Global( 427)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Jigs Chemical ltd +919099003427 Gujarat, India 239 58 Inquiry
VASUDHA PHARMA CHEM LIMITED +91-91-4044763666 +91-9396659284 Telangana, India 102 58 Inquiry
A.R. LIFE SCIENCES PVT. LTD. +91-914040267679 +91-8519993257 Hyderabad, India 100 58 Inquiry
ANWITA APIS +919000311012 Hyderabad, India 198 58 Inquiry
KARPSCHEM LABORATORIES +91-7249203006 +91-7249203006 Maharashtra, India 786 58 Inquiry
Lee Pharma Ltd +91-9849085929 +91-9849085929 Hyderabad, India 42 58 Inquiry
Nosch Labs Pvt Ltd +91-4048557474 +91-9948222287 Hyderabad, India 58 58 Inquiry
Afton Pharma +91-9712000202 +91-9712000202 Gujarat, India 63 58 Inquiry
Chempifine Chemicals +91-2225667766 +91-2225667766 Punjab, India 144 58 Inquiry
Dr. ASCRO Bio Sciences Private Limited +undefined-7382260502 +undefined-+91 9182680914 Telangana, India 51 58 Inquiry
Supplier Advantage
Jigs Chemical ltd 58
VASUDHA PHARMA CHEM LIMITED 58
A.R. LIFE SCIENCES PVT. LTD. 58
ANWITA APIS 58
KARPSCHEM LABORATORIES 58
Lee Pharma Ltd 58
Nosch Labs Pvt Ltd 58
Afton Pharma 58
Chempifine Chemicals 58
Dr. ASCRO Bio Sciences Private Limited 58

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Dabigatran etexilate Spectrum

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Pradaxa (dabigatran) Dabigatran Etexilate (free base) Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester BIBR-1048(Dabigatran etexilate) BIBR 1048 Prazaxa (E)-ethyl 3-(2-((4-(N'-(hexyloxycarbonyl)carbamimidoyl)phenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate BIBR-1048, >=99% Ethyl 3-(2-((4-(N-(hexyloxycarbonyl)carbamimidoyl)phenylamino)methyl)-1-methyl-N-(pyridin-2-yl 1-methyl-2-[N-[4-(-n-hexyloxycarbonylamidino) phenyl]aminomethyl]benzimidazol-5-yl- carboxylicacid-N-(2-pyridyl)-N- (2-ethoxycarbonylethyl)amide N-[2-[4-[N-(Hexyloxycarbonyl)amidino]phenylaminomethyl]-1-methyl-1H-benzimidazol-5-ylcarbonyl]-N-(2-pyridyl)-beta-alanine ethyl ester(Dabigatran etexilate) Ethyl 3-(((2-(((4-((((hexyloxy) carbonyl) amino) iminomethyl) phenyl) amino)\methyl)-1-methyl-1H-benzimidazol-5-yl)\carbonyl)(pyridin-2-yl)amino) propanoate Dabigatran etexilate N-[2-[4-[N-(Hexyloxycarbonyl)amidino]phenylaminomethyl]-1-methyl-1H-benzimidazol-5-ylcarbonyl]-N-(2-pyridyl)-beta-alanine ethyl ester Dabigatran etexilate (Dabigatran etexilate methanesulfonate) phenolsulphophthaleine sodium salt PR sodium salt Dabigatran Etexilatr CS-62 BIBR 1048; DABIGATRAN ETEXILATE;BIBR1048 Dabigatran Free Base abigatranetexilate Ethyl N-[[2-[[4-[N-[(Hexyloxy)carbonyl]carbamimidoyl]anilino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alaninate Ethyl 3-[2-[[[4-[N-[(Hexyloxy)carbonyl]carbamimidoyl]phenyl]amino]methyl]-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidaz Dabigatran etexilate USP/EP/BP Hexyl 2-(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbamoyl)-1-methyl-1H-benzo[d]imidazol-2-yl)methyl)amino)benzylidene)hydrazinecarboxylate Ethyl 3-(((2-(((4-(((( hexyloxy)carbonyl)amino)iminomethyl)pheny l)amino)methyl)-1-methy-lH-benzimidazole-5- yl)carbonyl)(pyridin-2-yl)amino)propanoate/ N-[2-[4-[N-(Hexyloxycarbonyl)amidino]phenylaminomethyl]-1-me... Dabigatran etexilate impurity1516 Dabigatran EtexilateQ: What is Dabigatran Etexilate Q: What is the CAS Number of Dabigatran Etexilate Q: What is the storage condition of Dabigatran Etexilate Q: What are the applications of Dabigatran Etexilate N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMidino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridyl-beta-alanine,ethyl ester N-[2-[4-[N-(Hexyloxycarbonyl)aMidino]phenylaMinoMethyl]-1-Methyl-1H-benziMidazol-5-ylcarbonyl]-N-(2- Etexilate BIBR-1048 (Dabigatran) Dabigatran ester DL- BIBR-1048 N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-Alanine, ethyl ester Dabigatran etexilate （Mesylat） ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester DBG-3A/DBG-3 (DABIGATRAN IMPURITY) DABIGATRAN ETEXILATE 35%, 40.0%, 43%, 50% W/W PELLETS Dabigatran Etexilate N-[[2-[[[4- [[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methy l]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β- Alanine Ethyl Ester Dabigatran P-1 Dabigatran (BIBR-1048) etexilate 211915-06-9 C34H41N7O5 Pharmaceutical intermediate API Dabigatran etexilate Other APIs