Fendiline
- CAS No.
- 13042-18-7
- Chemical Name:
- Fendiline
- Synonyms
- N-(1-Phenylethyl)-3,3-diphenylpropylamine;3,3-diphenyl-N-(1-phenylethyl)propan-1-amine;Benzenepropanamine, γ-phenyl-N-(1-phenylethyl)-
- CBNumber:
- CB4874928
- Molecular Formula:
- C23H25N
- Molecular Weight:
- 315.45
- MOL File:
- 13042-18-7.mol
- Modify Date:
- 2024/10/28 23:16:16
Fendiline Chemical Properties,Uses,Production
Originator
Sensit,Thiemann,W. Germany,1974
Manufacturing Process
21.13 grams of γ,γ-diphenyl-propylamine and 12.01 grams of acetophenone
are hydrogenated in 200 ml of methanol at 55°C and a pressure of 10
atmospheres in the presence of palladium charcoal. On filtration of the
catalyst the solution is concentrated and the remainder is distilled in vacuo at
a pressure of 0.3 Hg mm. The main distillate is collected at 206° to 210°C.
25.38 grams of N-[1'-phenylethyl-(1')]-1,1-diphenyl-propyl-(3)-amine are
obtained.
The product is dissolved in 134 ml of 96% ethanol whereupon 26.8 ml of
concentrated hydrochloric acid and 201 ml of water are added while cooling
with ice-water. The precipitate is filtered off and dried in vacuo at 100°C.
22.98 grams of N-[1'-phenylethyl)-(1')]-1,1-diphenyl-propyl-(3)-amine
hydrochloride are obtained. MP 200° to 201°C. On recrystallization from 285
ml of a 2:1 mixture of water and 96% ethanol the melting point remains
unchanged.
Therapeutic Function
Coronary vasodilator
Fendiline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 8772 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +8613564774135 | United States | 19881 | 58 | Inquiry |
| Hubei Nordina Biotechnology Co., Ltd. | 19371278702 | China | 971 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 15002134094 | China | 19727 | 58 | Inquiry |
| 3B Scientific Corporation | 847.281.9822 | United States | 6718 | 47 | Inquiry |
| 2A PharmaChem USA | (630) 737-0988 | United States | 6137 | 39 | Inquiry |
| Waterstone Technology, LLC | 317 644 0862 | United States | 6786 | 30 | Inquiry |
| Leancare Ltd. | +33 962096793 | United Kingdom | 6446 | 42 | Inquiry |
| Supplier | Advantage |
|---|---|
| Shaanxi Didu New Materials Co. Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| Hubei Nordina Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| 3B Scientific Corporation | 47 |
| 2A PharmaChem USA | 39 |
| Waterstone Technology, LLC | 30 |
| Leancare Ltd. | 42 |
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