ambenonium chloride
- CAS No.
- 115-79-7
- Chemical Name:
- ambenonium chloride
- Synonyms
- Mytelase;Ambestigmin;ambenonium chloride;ambenonium chloride USP/EP/BP;(2-chlorobenzyl)-[2-[[2-[2-[(2-chlorobenzyl)-diethyl-ammonio]ethylamino]-2-keto-acetyl]amino]ethyl]-diethyl-ammonium dichloride;(2-chlorophenyl)methyl-[2-[[2-[2-[(2-chlorophenyl)methyl-diethylazaniumyl]ethylamino]-2-oxoacetyl]amino]ethyl]-diethylazanium dichloride;(2-chlorophenyl)methyl-[2-[[2-[2-[(2-chlorophenyl)methyl-diethyl-azaniumyl]ethylamino]-2-oxo-ethanoyl]amino]ethyl]-diethyl-azanium dichloride
- CBNumber:
- CB4897314
- Molecular Formula:
- C28H42Cl2N4O2.2Cl
- Molecular Weight:
- 608.478
- MOL File:
- 115-79-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| Hazard Codes | T+ |
| Risk Statements | 28 |
| Safety Statements | 28-36/37-45 |
| Toxicity | LD50 oral in rat: 18500ug/kg |
ambenonium chloride Chemical Properties,Uses,Production
Definition
ChEBI: A symmetrical oxalamide-based bis-quaternary ammonium salt having ethyl and 2-chlorobenzyl groups attached to the nitrogens.
General Description
Ambenonium chloride, [oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethylammonium]dichloride (Mytelase chloride), is a white, odorlesspowder, soluble in water and alcohol, slightly soluble inchloroform, and practically insoluble in ether and acetone.Ambenonium chloride is used for the treatment of myastheniagravis in patients who do not respond satisfactorily toneostigmine or pyridostigmine.
This drug acts by suppressing the activity of AChE. Itpossesses a relatively prolonged duration of action andcauses fewer side effects in the GI tract than the other anticholinesteraseagents. The dosage requirements vary considerably,and the dosage must be individualized accordingto the response and tolerance of the patient. Because of itsquaternary ammonium structure, ambenonium chloride isabsorbed poorly from the GI tract. In moderate doses, thedrug does not cross the blood-brain barrier. Ambenoniumchloride is not hydrolyzed by cholinesterases.
ambenonium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | China | 2931 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24607 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | China | 9311 | 58 | Inquiry |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | China | 8141 | 58 | Inquiry |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | China | 1249 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 23963 | 58 | Inquiry |
| BOC Sciences | USA | 0 | 65 | Inquiry |