Demecarium bromide
- CAS No.
- 56-94-0
- Chemical Name:
- Demecarium bromide
- Synonyms
- 2br;bc48;e)(2:1);tonilen;humorsol;tosmicil;tosmilen;tosmilene;visumatic;frumtosnil
- CBNumber:
- CB6501408
- Molecular Formula:
- C32H52Br2N4O4
- Molecular Weight:
- 716.59
- MOL File:
- 56-94-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/21 10:59:17
| Melting point | 162-167 °C (decomp) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO:160.0(Max Conc. mg/mL);223.28(Max Conc. mM) |
| form | Solid |
| color | White |
| InChIKey | YHKBUDZECQDYBR-UHFFFAOYSA-L |
| SMILES | C1(=CC=CC([N+](C)(C)C)=C1)OC(=O)N(C)CCCCCCCCCCN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1.[Br-].[Br-] |
| CAS DataBase Reference | 56-94-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2924296000 |
Demecarium bromide Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Demecarium is a disymmetrical compound that contains two ammonium and two carbamate groups. It is a reversible cholinesterase inhibitor that is longer lasting than the others. It is used to constrict pupils, elevate intraocular pressure in treating glaucoma, and also for alleviating atropine mydriasis.
Uses
Demecarium Bromide is an acetylcholinesterase inhibitor and veterinary medicine used to treat elevated intraocular pressure associated with primary glaucoma.
Definition
ChEBI: The methobromide salt of the N,N'-bis[3-(dimethylamino)phenyl carbamate] derivative of 2,13-diazatetradecane. It is an inhibitor of acetylcholinesterase and pseudocholinesterase, with a long duration of action. It is u ed in the treatment of chronic open-angle glaucoma: in the eye, it causes constriction of the iris sphincter muscle and the ciliary muscle, facilitating the outflow of the aqueous humor and so reducing intraocular pressure.
General Description
Demecarium bromide,(m-hydroxyphenyl)trimethylammonium bromide, decamethylenebis[methylcarbamate] (Humorsol), is the diester of(m-hydroxyphenyl)trimethylammonium bromide with decamethylene-bis-(methylcarbamic acid) and thus is comparableto a bis-prostigmine molecule.
It occurs as a slightly hygroscopic powder that is freelysoluble in water or alcohol. Ophthalmic solutions of the drughave a pH of 5 to 7.5. Aqueous solutions are stable and maybe sterilized by heat. Its efficacy and toxicity are comparableto those of other potent anticholinesterase inhibitor drugs. Itis a long-acting miotic used to treat wide-angle glaucomaand accommodative esotropia. Maximal effect occurs hoursafter administration, and the effect may persist for days.
Synthesis
Demecarium, N,N??-decamethylene-bis-[meta-(N-methylcarbamoyloxy)- phenyl-trimethylammonium] hydroxide (13.2.18), is made by reacting two moles of phosgene with 1,10-bis-(methylamino)-decano(N,N??-dimethyldecamethylen-1,10-diamine, giving the bis-carbamoylchloride (13.2.16), which is transformed into bis-carbamoylester (13.2.17) by reaction with two moles of the 3-dimethylaminophenol sodium salt. Reacting this with methylbromide gives demecarium (13.2.18) [49].
Demecarium bromide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd | +86-02223869539 +86-15560057295 | China | 27 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9338 | 55 | Inquiry |
| Tianjin Huiren Chemtech Co., Ltd | +86-86-22-23707858 +86-86-13672008665 | China | 171 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |