sorivudine
- CAS No.
- 77181-69-2
- Chemical Name:
- sorivudine
- Synonyms
- YN-72;BvAraU;D01734;BV-araU;Bravavir;Brovavir;Sorivudin;sorivudine;Bravavir (tn);Sorivudine (jan/usan/inn)
- CBNumber:
- CB51074625
- Molecular Formula:
- C11H13BrN2O6
- Molecular Weight:
- 349.13
- MOL File:
- 77181-69-2.mol
- Modify Date:
- 2024/7/2 8:55:09
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice (mg/kg): ~3300 i.p.; >5000 s.c.; >10000 orally (Machida, Sakata, 1984) |
|---|
sorivudine Chemical Properties,Uses,Production
Description
Sorivudine is an orally-active antiviral nucleoside analog. It has potent and selective
activity against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus (VZV). In a
cutaneous model infection of mice with HSV-1, oral administration of sorivudine at dose of
20 mg/kg resulted in a significant increase in the survival rate. Five percent sorivudine cream
is also useful in the topical treatment of cutaneous HSV-1 infection, including
immunocompromised patients. It has been suggested that its antiviral activity may be
mediated by inhibition of DNA synthesis in virus infected cells.
Since the metabolite of sorivudine inhibits the enzyme for pyrimidine catabolism,
caution should be taken not to use sorivudine in combination with fluorouracil drugs in order to
avoid hematological disorders.
Uses
Sorivudine is an antimetabolite drug and can be used to synthesize antiviral compounds as well as compounds that can treat diseases of viral etiol.
sorivudine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10978 | 58 | Inquiry |
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046 | China | 5822 | 58 | Inquiry |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | China | 4552 | 58 | Inquiry |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | China | 39992 | 58 | Inquiry |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | China | 18488 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24016 | 58 | Inquiry |
| InvivoChem | 13549236410 | China | 6749 | 58 | Inquiry |
| Hangzhou Jinghao Biotechnology Co., LTD | 17513242016 17513242016 | China | 2801 | 58 | Inquiry |
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