sorivudine manufacturers and suppliers in india

sorivudine

CAS:: 77181-69-2

MF:: C11H13BrN2O6

MW:: 349.13

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Properties

Melting point:: 182° (Sakata, 1980); mp 195-200° (dec) (Machida, Sakata, 1983)

alpha: D25 +0.5° (1N NaOH)

Density: 1.979±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

solubility: DMSO: 250 mg/mL (716.07 mM)

form: Solid

pka: 8.37±0.10(Predicted)

color: White to off-white

Safety Information

Toxicity: LD50 in mice (mg/kg): ~3300 i.p.; >5000 s.c.; >10000 orally (Machida, Sakata, 1984)

Use

Sorivudine is an orally-active antiviral nucleoside analog. It has potent and selective activity against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus (VZV). In a cutaneous model infection of mice with HSV-1, oral administration of sorivudine at dose of 20 mg/kg resulted in a significant increase in the survival rate. Five percent sorivudine cream is also useful in the topical treatment of cutaneous HSV-1 infection, including immunocompromised patients. It has been suggested that its antiviral activity may be mediated by inhibition of DNA synthesis in virus infected cells.Since the metabolite of sorivudine inhibits the enzyme for pyrimidine catabolism, caution should be taken not to use sorivudine in combination with fluorouracil drugs in order to avoid hematological disorders.