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SB218078

SB218078 Structure
CAS No.
135897-06-2
Chemical Name:
SB218078
Synonyms
SB218078 ?SB-218078;9,10,11,12-Tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione;9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione, 9,10,11,12-tetrahydro-
CBNumber:
CB51075435
Molecular Formula:
C24H15N3O3
Molecular Weight:
393.39
MOL File:
135897-06-2.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:09
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SB218078 Properties

Melting point >340 °C
Density 1.80±0.1 g/cm3(Predicted)
storage temp. Store at RT
solubility ≤5mg/ml in DMSO;5mg/ml in dimethyl formamide
form crystalline solid
pka 9.75±0.20(Predicted)
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

SB218078 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 559402 SB 218078 - CAS 135897-06-2 - Calbiochem A cell-permeable, ATP-competitive, and reversible indolocarbazole derivative that acts as a potent and selective inhibitor of checkpoint kinase (Chk1) 135897-06-2 1MG ₹19050 2022-06-14 Buy
Product number Packaging Price Buy
559402 1MG ₹19050 Buy

SB218078 Chemical Properties,Uses,Production

Description

SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM. It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 μM. SB 218078 releases G2 cell cycle arrest induced by γ-irradiation or the topoisomerase I inhibitor topotecan . In this way, SB 218078 enhances the cytotoxicity of DNA-damaging compounds.

Uses

SB 218078 is a selective inhibitor of Chk1.

Biological Activity

Inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC 50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G 2 cell cycle arrest caused by γ -irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics.

SB218078 Preparation Products And Raw materials

Raw materials

Preparation Products

SB218078 Suppliers

Global( 25)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9155 58 Inquiry
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 China 4398 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8740 58 Inquiry
Service Chemical Inc. 888-895-6920 Germany 6373 71 Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 China 15848 69 Inquiry
Spectrum Chemical Manufacturing Corp. 021-021-021-67601398-809-809-809 15221380277 China 9664 60 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
Nantong QuanYi Biotechnology Co., Ltd 58
Cayman Chemical Company 81
Shanghai Yifei Biotechnology Co. , Ltd. 58
Service Chemical Inc. 71
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Spectrum Chemical Manufacturing Corp. 60

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9,10,11,12-Tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione SB218078 ?SB-218078 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione, 9,10,11,12-tetrahydro- 135897-06-2