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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >SB218078

SB218078

SB218078 Structure
  • ₹19050
  • Product name: SB218078
  • CAS: 135897-06-2
  • MF: C24H15N3O3
  • MW: 393.39
  • EINECS:
  • MDL Number:MFCD27991263
  • Synonyms:9,10,11,12-Tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione;SB218078 ?SB-218078;9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione, 9,10,11,12-tetrahydro-
Price1 Properties Safety Information Description
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Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • ManufacturerSigma-Aldrich(India)
  • Product number559402
  • Product descriptionSB 218078 - CAS 135897-06-2 - Calbiochem A cell-permeable, ATP-competitive, and reversible indolocarbazole derivative that acts as a potent and selective inhibitor of checkpoint kinase (Chk1)
  • Packaging1MG
  • Price₹19050
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 559402 SB 218078 - CAS 135897-06-2 - Calbiochem A cell-permeable, ATP-competitive, and reversible indolocarbazole derivative that acts as a potent and selective inhibitor of checkpoint kinase (Chk1) 1MG ₹19050 2022-06-14 Buy

Properties

Melting point :>340 °C
Density :1.80±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :≤5mg/ml in DMSO;5mg/ml in dimethyl formamide
form :crystalline solid
pka :9.75±0.20(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM. It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 μM. SB 218078 releases G2 cell cycle arrest induced by γ-irradiation or the topoisomerase I inhibitor topotecan . In this way, SB 218078 enhances the cytotoxicity of DNA-damaging compounds.

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