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Caspofungin acetate

CAS No.: 179463-17-3

Chemical Name:: Caspofungin acetate

Synonyms: Cancidas;Caspofungin Diacetate;(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate;Mk0991;Mk 0991;L 743872;L-743872;L 743873;L-743,872;L 743,872

CBNumber:: CB51120146

Molecular Formula:: C54H92N10O17

Molecular Weight:: 1153.38

MOL File:: 179463-17-3.mol

MSDS File:: SDS

Modify Date:: 2023/11/13 16:15:56

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Caspofungin acetate Properties

Melting point	>105°C (dec.)
storage temp.	-20°C
solubility	H2O: soluble15mg/mL (clear solution)
form	powder
color	white to beige
InChIKey	OGUJBRYAAJYXQP-LLXMLGLCSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H317-H319-H335

Precautionary statements

P261-P280-P305+P351+P338

WGK Germany

RTECS

TP8046500

NFPA 704

	0
3		0

Caspofungin acetate price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0425	Caspofungin diacetate ≥97% (HPLC)	179463-17-3	5MG	₹10727.58	2022-06-14	Buy
Sigma-Aldrich(India)	SML0425	Caspofungin diacetate ≥97% (HPLC)	179463-17-3	25MG	₹43408.25	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML0425	5MG	₹10727.58	Buy
SML0425	25MG	₹43408.25	Buy

Caspofungin acetate Chemical Properties,Uses,Production

Description

Caspofungin is the first in a new class of antifungal agents named echinocandin to be launched in the US for the parenteral treatment of invasive aspergillosis in patients refractory to, or intolerant of other antifungal therapies such as amphotericin-B₁ lipid formulation of amphotericin-B and/or itraconazole. Caspofungin is a water soluble, stable, aza-substituted semisynthetic derivative of pneumocandin B, a fermentation product of the fungus Zalerion arboricola. Since fungi and humans are both eukaryotes, new antifungal agents must focus on fungus-specific targets in order to minimize potential toxicity in the human host. In this respect, the lipopeptide caspofungin, inhibits the synthesis of 1,3-beta- D-glucans present only in the fungal cell wall, which leads to the specific lysis of the pathogenic cells. The compound is fungicidal rather than fungistatic, an unusual feature among antifungal agents. Caspofungin has activity in vitro and in vivo against a range of Candida species (including azole and amphotericin B resistant Candida) and also against Aspergillus, an important pathogen which is not susceptible to fluconazole. Caspofungin was generally more active than amphotericin B, flucytosine, fluconazole and itraconazole against Candida species. Cryptococcus is not susceptible to caspofungin. Caspofungin has a half-life in human beings around 10 hours. Unlike the azoles, caspofungin does not inhibit cytochrome P450. The drug has been given intravenously with loading dose of 70 rag, followed by 50 mg daily to be effective in invasive aspergillosis refractory to prior antifungal therapy. Most of the side effects were mild and comprised fever, thrombophlebitis, headache, nausea, rash and flushing.

Chemical Properties

White Solid

Uses

Caspofungin Diacetate is an impurity of Caspofungin Acetate(C184900) which is an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.

Definition

ChEBI: The diacetate salt of caspofungin. It is used for the treatment of invasive candidiasis, and of aspergillosis in patients who are refractory to, or intolerant of, other therapy.

Caspofungin acetate Preparation Products And Raw materials

Raw materials

Preparation Products

Caspofungin acetate Suppliers

Global( 347)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Gland Pharma Ltd	+91-7075736524 +91-9700602423	Telangana, India	44	58	Inquiry
Sumar Biotech LLP	+91-7984183709 +91-9824575381	Gujarat, India	22	58	Inquiry
Vijaya Pharma And Life Science	+91-8939866271 +91-8939866271	Tamil Nadu, India	320	58	Inquiry
Gufic Group	+91-2267261000 +91-2267261000	Maharashtra, India	22	58	Inquiry
BDR Pharmaceuticals International Pvt Ltd	+91-2240560560 +91-7718884418	Maharashtra, India	206	58	Inquiry
MSN LIFE SCIENCES PRIVATE LTD	+91 84523 34200	New Delhi, India	104	58	Inquiry
GLAND PHARMA LTD	+91-40-30510999	New Delhi, India	52	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry

Supplier	Advantage
Ralington Pharma	58
Gland Pharma Ltd	58
Sumar Biotech LLP	58
Vijaya Pharma And Life Science	58
Gufic Group	58
BDR Pharmaceuticals International Pvt Ltd	58
MSN LIFE SCIENCES PRIVATE LTD	58
GLAND PHARMA LTD	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58

Caspofungin acetate Spectrum

Caspofungin acetate(179463-17-3)MS

179463-17-3(Caspofungin acetate)Related Search:

Acetic acid Tocopheryl acetate S-Adenosyl-L-methionine Sodium acetate trihydrate Sodium acetate

Butyl acetate Potassium Acetate Ethyl acetate Glatiramer acetate Methyl acetate

Caspofungin Vinyl acetate ACETATE Caspofungin acetate

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Caspofungin acetate Caspofungin acetate [USAN:BAN:JAN] L 743,872 L 743872 L-743,872 L-743872 Mk 0991 Mk0991 Pneumocandin B0, 1-((4R,5S)-5-((2-aminoethyl)amino)-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine)-5-((3R)-3-hydroxy-L-ornithine)-, diacetate (salt) 1-[(4R,5S)-5-[(2-AMinoethyl)aMino]-N2-[(10R,12S)-10,12-diMethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-(threo-3-hydroxy-L-ornithine)pneuMocandin B0 Diacetate 1-[(4R,5S)-5-[(2-AMinoethyl)aMino]-N2-[(10R,12S)-10,12-diMethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]pneuMocandin B0 Diacetate L 743873 Cancidas, L-743,872, MK-0991 Cancidas (Caspofungin Acetate) Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2) (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1 Caspofungin acetate Cancidas 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0 Caspofungin diacetate, >=98% Casp ungin Acetate Caspofungin Acetate (L 743872 Caspofungin Acetate for lnjection Cancidas, ≥98% Casporfungin Acetate CF/KB(EUGMP,GMP) L 743872;L 743873;MK 0991;MK-0991 Caspofungin acetate USP/EP/BP Caspofungin diacetate salt Caspofungin acetate B0 pofungin Acetate (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide diacetate Caspofungin Acetate (MK0991) (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrol US-DMF No.: 034091 ASMF Approved Caspofungin Diacetate Cancidas (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate Bamifylline Impurity 2 Caspofungin Acetate (>90%) Carpofungin acetate Gaspofungin Acetate (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide acetate (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide diacetate (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-C:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide acetate 179463-17-3 179643-17-3 79463-17-3 C56H96N10O19 C52H88N10O152C2H4O2 API Amines Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals